Our high purity Tadalafil powder CAS 171596-29-5 is produced via asymmetric chiral synthesis and multi-stage low-temperature recrystallization purification, aligned with USP and EP testing guidelines for pharmaceutical research intermediates. The finished white crystalline powder features fine uniform particle sizing, low moisture absorption, total related impurities held below 0.35%, and steady HPLC purity between 99.1% and 99.5%. Controlled chiral separation processes limit enantiomeric impurity to under 0.08%, a critical metric for consistent results during in vitro enzyme testing.
We supply bulk tadalafil research materials to research facilities worldwide, offering small trial packaging for initial lab screening and kilogram-scale bulk orders for ongoing formulation research workflows.
We address common procurement hurdles for B2B buyers: limited access to independent third-party chiral purity verification, incomplete documentation for cross-border customs clearance, powder moisture or leakage risks during international transit, inconsistent enantiomer levels between batches, and limited technical guidance for adjusting crystal recrystallization parameters.
This tadalafil raw material fits university pharmacology labs studying vascular signaling pathways, independent polymorph research institutes, chiral API synthesis workshops and analytical reference standard labs. Stable batch metrics reduce deviation in experimental data and cut material evaluation costs for new compound development programs.
Product Specification Table
All physical and chemical metrics are tested within our in-house analytical laboratory. Every batch of Tadalafil powder CAS 171596-29-5 can be submitted for re-inspection by certified third-party labs including SGS and Eurofins.
|
Test Item |
Standard Specification |
Actual Batch Test Result |
|
Product Name |
Tadalafil Base Powder |
Compliant |
|
CAS Registry Number |
171596-29-5 |
Compliant |
|
Full IUPAC Name |
(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione |
Compliant |
|
Molecular Formula |
C₂₂H₁₉N₃O₄ |
Compliant |
|
Molecular Weight |
389.41 g/mol |
Compliant |
|
HPLC Main Component Purity |
≥99.0% (Research Grade USP Standard) |
99.38% |
|
Enantiomeric Impurity |
≤0.10% |
0.07% |
|
Appearance |
White fine crystalline powder, odorless |
Uniform white crystalline powder |
|
Melting Point Range |
293℃ ~ 297℃ |
295.1℃ |
|
Solubility Profile |
Soluble in DMSO, dichloromethane; slightly soluble in methanol, ethanol; insoluble in purified water |
Compliant |
|
Loss on Drying (105℃, 2h) |
≤0.4% |
0.18% |
|
Residue on Ignition |
≤0.1% |
0.03% |
|
Total Related Substances |
≤0.5% |
0.32% |
|
Single Maximum Individual Impurity |
≤0.08% |
0.05% |
|
Heavy Metal Residues (Pb, As, Hg, Cd) |
≤10 ppm |
<1 ppm |
|
Storage Requirements |
Hermetically sealed, light-proof, cool dry storage; avoid high humidity and UV light exposure |
Standard compliant |
|
Shelf Life |
24 months under recommended sealed storage |
Valid |
Packaging Options for International Orders
Packaging is an easy part of a purchase to overlook until the material is already in transit.
For pharmaceutical raw materials, the package needs to protect the material during normal handling, storage and transportation while also being practical for warehouse operations.
Typical packaging can be arranged according to order quantity and customer requirements.
| Packaging Item | Supply Information |
|---|---|
| Product Form | Bulk powder |
| Inner Packaging | Protective sealed inner bags |
| Outer Packaging | Export-suitable container |
| Sample Packaging | Small quantity packaging for evaluation |
| Bulk Packaging | Arranged according to order quantity |
| Label Information | Confirmed before shipment |
| Shipping Marks | Prepared according to customer requirements where applicable |
Before shipment, packaging details can be confirmed with the customer, including:
● Net weight
● Gross weight
● Number of packages
● Product name
● Batch information
● Shipping marks
● Destination information
This gives the receiving team a clearer picture of the shipment before it arrives.
Storage and Handling
Tadalafil Powder should be handled and stored according to the applicable SDS and product-specific documentation.
General material management practices include:
● Keep the container properly closed
● Store in a suitable dry environment
● Protect the material from unnecessary moisture exposure
● Avoid prolonged direct sunlight
● Follow the applicable SDS recommendations
● Maintain appropriate warehouse records
The exact storage requirements should be confirmed against the batch documentation supplied with the material.
Customers should also follow their own internal procedures for pharmaceutical raw material handling and storage.
Primary Application Scenarios for B2B Buyers of Tadalafil Powder CAS 171596-29-5
As a distinct long-acting selective PDE5 inhibitor research intermediate with unique chiral structure, high purity tadalafil powder serves four separate groups of institutional B2B buyers with specialized R&D use cases, distinct from short-acting PDE5 raw material applications:
University Vascular Pharmacology & Drug Metabolism Labs
Medical schools and life science research institutes source Tadalafil powder CAS 171596-29-5 for long-duration PDE5 enzyme binding kinetic assays, nitric oxide signal pathway long-term research, and side-by-side pharmacokinetic testing against other PDE5 inhibitors. Strictly controlled enantiomeric impurities reduce interference during biological testing, generating consistent experimental data suitable for academic manuscript submission. Small trial packaging (10g, 50g, 100g) caters to low-volume preliminary compound screening tests.
Pharmaceutical Polymorph & Formulation R&D Institutes
API polymorph research centers and compound formulation labs order bulk tadalafil raw material for crystal form polymorphism screening, solid dispersion solubility optimization and sustained-release prototype formulation compatibility trials. Low total related impurities stabilize recrystallization results and reduce unknown variables during sustained-release delivery system development. Medium and bulk packaging sizes (500g, 1kg, 5kg, 25kg) support uninterrupted long-term supply for ongoing formulation research programs.
Independent Analytical Reference Standard Labs
Third-party testing facilities use tadalafil powder as a certified reference standard for chiral HPLC instrument calibration, PDE5 small-molecule residue detection and chiral analytical method validation trials. Tightly regulated enantiomer and heavy metal levels meet strict quality benchmarks for certified laboratory reference reagents.
Chiral Fine Chemical Synthesis Manufacturers
Organic chiral synthesis producers use tadalafil powder as a core reaction intermediate to develop novel long-acting PDE5 derivative compounds and fused-indole pharmaceutical raw material variants. Stable chiral configuration and consistent purity metrics maintain steady synthesis conversion rates and limit byproduct formation during multi-step asymmetric organic reaction sequences.
Complete After-Sales Support Policy
We built targeted after-sales support to resolve common procurement challenges when purchasing Tadalafil powder CAS 171596-29-5:
Free full supporting documentation
Every batch includes standard COA, dual HPLC chromatograms, MSDS, factory ISO9001 certificates and certificate of origin. Custom supplementary test reports covering full enantiomer scans and residual solvent profiling are available upon client request for internal audits or customs clearance. All paperwork supports global cross-border declarations and laboratory filing workflows.
professional chiral chemistry technical support
Our team of pharmaceutical chiral chemists answers questions regarding tadalafil powder light-proof storage practices, crystal recrystallization solvent ratios, chiral HPLC testing parameters, enzyme assay setup and formulation compatibility troubleshooting, alongside custom guidance for polymorph R&D workflow adjustments.
Refund and reshipment for production-linked quality deviations (defined scope)
If third-party chiral HPLC testing identifies insufficient purity, elevated enantiomeric impurities or irregular molecular characterization originating from our manufacturing process, we offer full order refunds or free product reshipment, and cover relevant third-party testing and logistics fees. This policy does not apply to quality shifts caused by improper storage, client operational errors or logistics carrier negligence.
Stable supply perks for long-term framework clients
Partners with annual fixed procurement agreements receive material within a consistent batch-to-batch chiral purity range, fixed tiered bulk pricing, priority spot stock allocation and staggered batch delivery options aligned with continuous lab testing and enterprise R&D cycles.
Customized flexible service options
Adjustable packaging sizes, additional custom testing panels focused on polymorph or chiral impurity metrics, exclusive annual bulk pricing frameworks, and free small sample supplies for new buyers to evaluate tadalafil powder chiral purity and lab performance before placing large orders.
Transit damage coverage
All shipments carry full cargo insurance covering loss, packaging leakage and moisture-induced powder degradation during transit. If product damage occurs due to carrier fault, we arrange free re-delivery with no extra costs for the buyer.
FAQ
Q: How is Tadalafil Powder packaged?
A: Packaging depends on the quantity and shipping requirements. Protective inner packaging and suitable outer containers can be arranged for bulk shipments.
Q: Can I send my own specification?
A: Yes. If your company has an internal specification or QC checklist, you can provide it before ordering so the available product information can be reviewed against your requirements.
Q: Can you support repeat orders?
A: Yes. Repeat supply can be discussed according to specification, purchasing quantity and delivery requirements.
Q: Can I request a sample before a bulk order?
A: Yes. Sample availability can be discussed for professional laboratory evaluation and supplier qualification.
Product Handling and Compliance Notice
Tadalafil is a pharmaceutical active ingredient, not an ordinary food or dietary supplement ingredient. Public FDA labeling identifies tadalafil as a prescription pharmaceutical active ingredient, and the labeling contains specific contraindications, warnings and drug-interaction information.
This page is intended to provide B2B raw material and supply information only.
It does not provide:
● Medical advice
● Patient treatment recommendations
● Human-use instructions
● Dosage recommendations
● Self-medication guidance
● Finished-product formulation instructions
Customers are responsible for ensuring that their intended purchase, handling, formulation and commercial use comply with the laws and requirements applicable to their market.
The raw material should only be handled by appropriately qualified professional organizations.
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