Supply Raw Materials For Sibutramine

Basic Product Information

Henan Jinyi Import and Export Co., Ltd. produces and sells high-quality raw materials of sibutramine (106650-56-0) with a purity of over 99%. Sibutramine is synthesized from 2-chloroacetonitrile as the starting material and cyclized with 1,3-dibromopropane under alkaline conditions to obtain the intermediate of cyclonitrile. The intermediate of secondary amine is obtained through Grignard addition and reduction, and then completed through Eschweiler Clark reaction. We have complete synthetic production equipment and a complete detection and analysis system, which can complete the entire process of synthesis, salt formation, recrystallization, and drying. We are equipped with HPLC and high-performance liquid chromatography detection instruments to strictly detect and control the purity of the product and related impurities.

We have an independent testing laboratory that uses high-performance liquid chromatography (HPLC) to test the purity and impurities of sibutramine samples. The purity of the main components in the samples can reach over 99%. The laboratory can analyze and monitor various impurities such as stereoisomers, process by-products, and residual solvents. Through refining processes, the levels of various impurities are effectively reduced, and the total impurities and single impurity limits are strictly controlled. Corresponding COA detection reports can be issued for each batch.

This product is a therapeutic drug for obesity. It mainly works through its amine (secondary and primary amine) metabolites, and its main mechanism is to inhibit the reuptake of norepinephrine, serotonin, and dopamine to enhance satiety, while having no significant effect on the release of norepinephrine, serotonin, and dopamine. The study also showed that this product and its amine active metabolites have no significant anticholinergic, antihistamine, or monoamine oxidase inhibitory effects.

1. Our company supports multi specification packaging, from gram level, hundred gram level to kilogram level packaging, which can match the needs of different stages of use from small-scale, pilot scale to large-scale production.
2. The gram level small packaging is vacuum sealed in a sealed aluminum foil bag, which is light and moisture resistant, suitable for laboratory research and development sampling, easy to sample and test, and less prone to material contamination.
3. The 100g specification uses thickened aluminum foil composite bags with built-in desiccants, which have strong sealing properties and are convenient for small batch testing by scientific research units. The material storage stability is good.
4. The inner layer of the kilogram grade is made of sterile PE inner film bag, and the outer layer is heat sealed with aluminum foil bag for double sealing, effectively isolating water vapor and oxygen, and ensuring the quality of raw materials.
5. The production packaging for large kilograms is packaged in cardboard drums, with a tightly sealed inner membrane and a reinforced and pressure resistant drum body, suitable for factory feeding production and easy storage and stacking.
6. All packaging specifications are fully labeled with product name, CAS number, batch number, net weight, production date, storage conditions, and complete information for easy traceability management.
7. Customized packaging specifications can be arranged as needed, ranging from a few grams of samples to tens of kilograms of industrial raw materials, supporting customers' special packaging requirements.
8. The entire packaging meets the storage and transportation standards for pharmaceutical raw materials, is suitable for domestic shipping and foreign trade export transportation, is leak proof and damage proof, and meets the requirements of long-distance logistics transportation.

The company has a comprehensive quality control system and can provide customers with complete pharmaceutical compliance qualification information. Each batch of products can be accompanied by COA analysis reports, HPLC detection spectra, MSDS safety technical manuals, and relevant qualification documents for enterprise production. All data formats are standardized and can be used for internal quality control audits, third-party testing and verification, as well as overseas customs declaration and compliance filing. They can fully meet the requirements of domestic and foreign customers for raw material qualification review and provide reliable document support for cooperative projects.

1. For pharmaceutical raw material export orders, we support multiple shipping modes including international express delivery, air freight, and LCL, and can flexibly adapt to small order shipping needs.
2. Familiar with cross-border customs declaration process, able to handle export declaration, simplify customs declaration procedures for small batches of goods, and shorten the shipping cycle.
3. The samples should be sealed and protected with moisture-proof, light proof, and leak proof packaging, and handled strictly in accordance with the cross-border transportation standards for pharmaceutical raw materials.
4. We can provide a complete set of documents including commercial invoices, packing lists, MSDS, and COA, with all necessary information to meet the customs inspection requirements of the destination country.
5. The entire logistics process of the goods can be tracked online, providing real-time feedback on the progress of collection, transit, customs clearance, and delivery, making it convenient for customers to grasp the status of the goods.
6. No need to pack the entire container, dozens of grams can be arranged for shipment, suitable for R&D sampling and customer sample orders.
7. Suitable logistics channels can be matched according to different destination countries, taking into account both transportation efficiency and logistics costs, with a wide range of choices.
8. Strictly control the packaging process, reinforce the outer box protection, reduce the risk of collision and damage during cross-border transit, and ensure the safe delivery of small batches of goods.

1. Provide exclusive after-sales docking services after order delivery, respond promptly to customer inquiries, and quickly handle various product related issues.
2. Retain samples for each batch of products. If there are quality objections, provide sample review and support third-party organization testing and verification.
3. If there is packaging damage or leakage during transportation, we can provide customers with solutions such as replacement and replenishment after verification.
4. Provide complete information such as COA, MSDS, and detection spectra. If there are missing or incorrect information, a new correction can be issued as soon as possible.
5. The technical team can provide product basic technical consultation, answer basic questions related to storage, use, and feeding.
6. Strictly control the quality inspection of shipments, review the weight, packaging, and batch number before shipment, and reduce the occurrence of wrong or insufficient shipments.
7. Establish order files, batch numbers can be traced throughout the process, making it convenient for customers to repurchase and trace product batch information in the future.
8. Respect different customer demands, handle after-sales disputes through friendly negotiation, and fully protect the reasonable rights and interests of the purchaser.
9. If the product is not satisfactory or damaged during transportation, our company will issue a full refund

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