High Content Sibutramine Hydrochloride Raw Material CAS84485-00-7

1. Chinese full name: Sibutramine hydrochloride (monohydrate)
2. English name: Sibutramine Hydrochloride Monohydrate
3. Chemical name: 1- (4-chlorophenyl) - N, N-dimethyl - α - (2-methylpropyl) cyclobutane methylamine hydrochloride monohydrate
4. CAS number: Free base: 106650-56-0 Anhydrous hydrochloride: 84485-00-7 Monohydrate hydrochloride: 125494-59-9
1. Molecular weight: 334.33
2. Appearance: White or off white crystalline powder, odorless, slightly bitter taste
3. Melting point: 191~192 ℃
4. Solubility: soluble in methanol, ethanol DMSO; Slightly soluble in water; Hygroscopic
5. Storage conditions: Store in a dark, sealed, cool and dry place, moisture-proof. It is recommended to store in a sealed place at 15-25 ℃

Sibutramine hydrochloride is a central monoamine reuptake inhibitor and a prodrug. It enters the human body and is metabolized by CYP3A4 in the liver to produce two active metabolites: N-monodemethylsibutramine (M1) and N, N-bisdemethylsibutramine (M2), which exert pharmacological effects. Principle of action: Inhibit presynaptic membrane 5-hydroxytryptamine and increase the concentration of neurotransmitters in the central synaptic cleft; Enhance satiety, reduce appetite, and increase basal energy expenditure to achieve weight loss.
Characteristics: Does not directly promote neurotransmitter release; No significant anticholinergic, antihistamine, or MAO inhibitory effects.

Sibutramine hydrochloride monohydrate is a white or off white crystalline powder, and some batches may present a very slight milky white color without visible colored impurities, clumps, mold spots, or foreign objects. This product has no special odor and has a slight bitter taste when tasted; The fineness of crystal powder varies depending on the production process. Conventional raw materials are fine powders, and some refining processes may result in small crystalline particles. The flowability of the powder is generally average, and slight compaction may occur after long-term storage and compression. After gentle dispersion, the powder state can be restored. This product has strong hygroscopicity and can quickly absorb water vapor when exposed to high humidity air environments. After being affected by moisture, the powder color darkens, clumps and becomes hard. When severely affected by moisture, it may become sticky and melt, resulting in a decrease in purity and an increase in related substances, which affects product quality. Under long-term direct exposure to light, the material will slowly degrade, gradually turning yellow in color and increasing in impurity content. Therefore, it is necessary to avoid light protection throughout the process.
Solubility reference: soluble in organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO); Slightly soluble in water; Almost insoluble in non-polar solvents such as n-hexane.
2, Storage method and complete storage requirements
1. Basic storage environment
It should be stored in a light shielded, sealed, cool, and dry environment. It is recommended to keep the temperature between 15 ℃ and 25 ℃ for long-term storage, and the relative humidity of the environment should be controlled below 60%. Keep away from heat sources, open flames, and direct sunlight, and avoid storing in areas with large temperature differences and strong sunlight such as windowsills, boilers, and high-temperature warehouses.
2. Packaging sealing requirements
The raw materials are packaged in polyethylene sealed bags and sealed in vacuum aluminum foil bags. The bulk barrel products are equipped with double-layer thick PE inner lining bags, sealed with zip ties, and the outer cardboard barrel is protected from light; After opening and using, the air inside the bag must be expelled as soon as possible, and the seal must be tightened again. If possible, a vacuum sealing machine can be used for secondary sealing to reduce contact with air and water vapor and prevent moisture absorption and degradation. Long term open placement is strictly prohibited.
3. Storage and stacking standards
The storage area should be well ventilated, and it is recommended to place moisture-proof trays on the ground. It is forbidden for raw material barrels/packaging bags to directly contact the ground to prevent moisture from penetrating the ground and causing dampness. Separate the stacking of different batches, keep a good identification ledger, and follow the first in, first out principle; Do not mix with strong acids, bases, oxidants, or volatile reagents to avoid chemical reactions or cross contamination.

High performance liquid chromatography method
1. Scope of application
Raw material purity testing, large-scale initial screening of simple matrix samples; Complex matrix health foods are prone to false positives, and positive samples must be rechecked by LC-MS/MS.
2. Brief operation
Sample methanol ultrasonic extraction, centrifugal filtration; A C18 reverse phase chromatography column is used, with acetonitrile ammonium acetate buffer salt system commonly used as the mobile phase. The UV detection wavelength is about 223 nm, and quantification is performed by external standard method.
3. Limitations
Low sensitivity, unable to distinguish structurally similar derivatives, only suitable for screening samples with higher content.

Our company specializes in various weight loss and slimming raw materials. In order to facilitate customers' formula research and development, process debugging, quality evaluation, and machine testing, we support customers to apply for sample samples for evaluation and testing in advance. All samples are taken from the corresponding formal production batches, with complete packaging specifications, effectively ensuring that the quality of small samples is consistent with that of bulk goods, and avoiding batch differences that may affect subsequent production. Provide a complete quality inspection report (COA) for this batch synchronously with the sample, which details the product's appearance, purity content, related substances, moisture, heavy metals, microorganisms, and other complete testing data, execution standards, and corresponding testing methods. The information is complete and traceable, meeting the customer's internal quality inspection, laboratory verification, filing review and other related information requirements. During the sample evaluation stage, our technical personnel can assist in answering inquiries related to raw material storage conditions, basic physical and chemical properties, and pre-treatment reference plans. After confirming that the quality of the customer's samples meets the standards, formal bulk procurement cooperation can be negotiated. For bulk orders, factory quality inspection documents will be issued batch by batch, supporting corporate signing and compliant invoicing. The product quality will be strictly controlled throughout the process to ensure stable supply. All raw materials are only allowed to be used in compliant application scenarios permitted by laws and regulations. The purchaser shall confirm on their own that the use of raw materials complies with relevant national regulatory requirements

By choosing to cooperate with our company, you can not only obtain stable quality raw material products, but also enjoy one-stop professional supporting services. Our company has been deeply involved in the field of raw material supply for many years, with mature and stable supply channels. We strictly control the factory quality of each batch of products, establish a complete control process from raw material production, packaging quality inspection to warehousing logistics, and achieve batch stability and controllable indicators. All products can provide corresponding batch quality inspection reports (COA), with complete testing data. Abundant supply, always in stock, most specifications can be quickly arranged for shipment without the need for long waiting times for production scheduling. A mature warehouse management system ensures stable inventory, can efficiently respond to customer procurement needs, and shorten delivery cycles. After the order is confirmed, we immediately check the inventory, arrange for packaging and outbound, follow up on logistics information throughout the process, synchronize the transportation status of goods in a timely manner, and ensure timely delivery of goods. At the same time, the product quality is strictly controlled, and sample testing and corresponding batch quality inspection reports can be provided. The supporting after-sales service is complete, the docking is efficient, the supply is stable and reliable, and it helps customers to smoothly advance projects without delaying research and development and production progress.

1. For conventional bulk goods, priority should be given to full truckload less than truckload logistics transportation, which is suitable for large quantities of barreled raw materials, with high cost-effectiveness and strong carrying capacity.
2. For small-scale samples and small quantities of goods, domestic mainstream express delivery can be chosen for fast delivery and door-to-door delivery.
3. For urgent orders, dedicated vehicles can be arranged for direct delivery to shorten transportation time and ensure fast delivery of goods.
4. For long-distance goods crossing provinces, use mainline dedicated logistics to reduce transit links and lower the risk of cargo damage.
5. If special transportation such as cold chain, light avoidance, and moisture prevention is required, a compliant logistics channel with temperature control and protection capabilities can be matched.
6. Support customers to specify cooperative logistics, and our company will cooperate to complete packaging handover and provide relevant shipping documents.
7. Foreign trade orders can be arranged with sea freight, air freight, international dedicated logistics, and assistance in organizing customs declaration supporting documents.
8. Local and nearby short distance orders support self pickup, and short distance delivery can also be arranged for flexible handover of goods.
9. Special controlled chemicals shall be transported by compliant logistics companies with hazardous chemical transportation qualifications in accordance with national regulations.

Our company always adheres to the business philosophy of "quality first, service foremost, integrity and win-win", establishes a comprehensive, standardized and all-round after-sales service guarantee system, and fully guarantees the legitimate rights and interests of every customer, providing stable and reliable full process service support for customer procurement, research and development, and production. All products leaving the factory undergo strict quality inspection, and each batch of goods can provide formal and effective quality inspection reports. The product information is true and complete, and the quality can be traced back to ensure stable and up to standard delivery quality.
In the process of order delivery, our company is equipped with dedicated after-sales liaison personnel to follow up on the progress of orders, warehousing and stocking, packaging and outbound, and logistics transportation dynamics throughout the process. We timely synchronize shipping information, logistics tracking numbers, and estimated arrival times with customers, effectively solving various problems such as customer shipping inquiries and progress inquiries. The company maintains sufficient stock of spot goods, with fast order response speed and high delivery efficiency, ensuring maximum customer procurement cycle without delaying customer experimental research and development and mass production progress.
After receiving the goods, if there are any abnormal situations such as packaging damage, shortage of goods, transportation damage, or discrepancies between the physical and batch standards, customers only need to provide relevant vouchers in a timely manner. We will respond quickly, verify and handle them, and provide free solutions such as replacement, exchange, negotiation and compensation to efficiently and properly solve after-sales problems. At the same time, we provide long-term professional technical consulting services, which can answer customers' questions about product storage methods, usage precautions, basic application parameters, and provide technical support throughout the process.
Our company adheres to standardized after-sales processes, refuses to procrastinate, and strives to provide attentive pre-sales, in sales, and after-sales services throughout the entire process. Kind reminder: The product needs to be stored in a dark, sealed, and dry place according to standard conditions. Quality problems caused by improper storage, unauthorized packaging, or illegal use by customers are not covered by after-sales guarantee. We strive to safeguard every customer with stable quality, efficient service, and honest operation

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