High Quality Sibutramine Raw Material Powder

Common name: Sibutramine
English name: Sibutramine
1. Naming: {1- [1- (4-chlorophenyl) cyclobutyl] -3-methylbutyl} dimethylamine
Molecular formula: C17H26ClN
Molecular weight: 334.32
2. Physical and chemical properties (free base)
Appearance: White to off white solid; Hydrochlorides are mostly white crystalline powders, odorless and slightly bitter
Solubility: Slightly soluble in water, soluble in some organic solvents;
Predicted boiling point: 342.6 ℃; pKa≈9.6
3. Mechanism of action
Sibutramine raw material powder enhances satiety, reduces food intake, and slightly increases energy expenditure

Sibutramine raw material has a purity of up to 99% and is prepared using advanced microbial refining and purification processes. Through multi-stage separation, crystallization, recrystallization, drying and screening, impurities, residual solvents, heavy metals, and miscellaneous bacteria are effectively removed. The finished product has a uniform white crystalline powder appearance, with loose and dry powder, good fluidity, and is not easy to agglomerate, possessing excellent solubility. The raw materials are strictly tested and verified for purity indicators using high-performance liquid chromatography (HPLC) before leaving the factory. Each batch comes with a complete COA test report, and all indicators comply with mainstream quality standards such as national standards, USP, EP, etc. At the same time, complete qualification documents are provided to ensure compliance with functional raw material export requirements. The core advantage of high purity lies in the stable content of active ingredients, minimal differences between batches, and ease of precise weighing and compatibility of downstream formulas, avoiding common problems such as fluctuations in product efficacy, abnormal flavor, and easy storage deterioration caused by excessive impurities in low purity raw materials. We can provide samples, customized packaging, formula technical support, and support long-term stable supply.

1. Sample
Sample crushing → Acetonitrile/methanol ultrasonic extraction → HLB/C18 solid-phase extraction purification or QuEChERS dispersion purification → Nitrogen blowing concentration, organic phase reconstitution, 0.22 μ m membrane filtration
2. Instrument reference conditions
Chromatographic column: C18/HSS T3 (100 mm × 2.1 mm, 1.8~2.7 μ m)
Mobile phase: Acetonitrile+0.1% formic acid aqueous solution (gradient elution)
Ion source: ESI+(electro spray positive ion), MRM multi reaction monitoring
Sibutramine characteristic ion pairs: m/z 378.2 → 162.1 (quantitative ion), supported by qualitative ion pairs
3. Detection limit (GB5009.88-2023)
LOD：0.01 mg/kg,LOQ：0.05 mg/kg; Recovery rate of 80%~120%

1. Sample/R&D grade packaging: suitable for small-scale use scenarios such as customer experimental research and development, formula debugging, sample testing, and process exploration. Adopting an inner layer of food grade PE sealed bag and an outer layer of vacuum aluminum foil light shielding packaging structure, vacuum compression sealing is used to prevent air and water vapor from penetrating, and the overall product has good moisture resistance, light shielding, shock resistance, and antioxidant properties. The standard packaging specification is 1kg/bag, with clean and tidy packaging, clear labeling, and easy sampling. It can be used directly after opening the box without the need for secondary packaging treatment.
2. Industrial production grade packaging: fully sealed and sealed, with reinforced and thickened barrel body that is resistant to pressure and wear. It can meet the requirements of long-distance logistics transportation and multi-layer stacking storage, and is not easily damaged, leaked, or damp. It fully complies with the safety regulations for chemical raw material storage and logistics transportation.
3. Research standard/reference packaging: For professional scenarios such as laboratory testing, instrument calibration, method validation, and quality control, light shielded brown penicillin bottles are vacuum sealed to effectively isolate the effects of light and temperature changes on the samples. The standard specifications include trace quantities such as 10mg, 50mg, 100mg, etc. Each bottle is independently packaged, clearly numbered, and traceable, and is suitable for use with various chromatographic and mass spectrometry detection equipment.
At the same time, the company supports customized packaging services based on customers' personalized needs, and can negotiate and adjust packaging specifications according to customers' actual production, experimental, and inspection needs, flexibly adapting to various usage scenarios. All product packaging is fully labeled with product name, specifications, batch number, production date, shelf life, storage conditions, and relevant quality inspection information. The information is complete, formal, and traceable.

Our company insists on putting customers at the center and providing full process supporting after-sales services. The product is accompanied by a COA quality inspection report upon delivery, which supports product quality verification and traceability. If the customer finds problems such as damaged packaging, inconsistent quantity, or abnormal batch quality after receiving the goods, please provide relevant documents such as photos in a timely manner. We will communicate and coordinate as soon as possible to negotiate a proper solution. In terms of technology, we can provide technical support such as standard product parameters, storage conditions, and basic application references. During the cooperation period, if there are any needs for order follow-up, logistics inquiry, stocking and scheduling, the dedicated liaison personnel will respond promptly and provide feedback. Kind reminder: Customers are required to strictly store according to the recommended product conditions, use raw materials in compliance with relevant national laws and regulations. Problems caused by improper storage or improper use are not covered by after-sales support.

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