Pharmaceutical Grade Sibutramine Raw Material

1. Chinese name: Sibutramine
2. Chinese alias: N - (1- (1- (4-chlorophenyl) cyclobutyl) -3-methylbutyl) - N, N-dimethylamine
3. English name: Sibutramine
4. CAS number: 106650-56-0
5. Molecular formula: C17H26ClN
6. Molecular weight: 279.85
7. Accurate quality: 279.17500
8.PSA：3.24000
9.LogP：4.73800
Physical and chemical properties
1. Appearance: White crystalline powder
2. Melting point: 191-192 ° C
Molecular structure data
1. Molar refractive index: 83.76
2. Molar volume (cm3/mol): 271.3
3. Waiting for Zhang Biarong (90.2K): 670.5
4. Surface tension (dyne/cm): 373.3
5. Polarization rate (10-24cm3): 33.2
6. Single isotope mass: 279.175378 Da
7. Nominal mass: 279 Da
8. Average quality: 279.848 Da
Calculate chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): 5.4
2. Number of hydrogen bond donors: 0
3. Number of hydrogen bond acceptors: 1
4. Number of rotatable chemical bonds: 5
5. Number of tautomers: 0
6. Topological molecular polarity surface area: 3.2
7. Number of heavy atoms: 19
8. Surface charge: 0
9. Complexity: 275
10. Number of isotopic atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 1
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Content: 99%
16: Detection method: Liquid phase chromatogram
17: Shelf life: 24 months
18: Storage method; Store in a cool and dry place, away from light.

1. Weigh 1g of solid sample, place it in a centrifuge tube, add methanol solvent, sonicate for 20 minutes, centrifuge at 4000 r/min for 5 minutes, take the supernatant, filter it through a 0.22 μ m organic filter membrane, and obtain the test solution; Complex matrices can increase solid-phase extraction purification and remove matrix interference.
2. C18/T3 chromatographic column is selected as the chromatographic column; The mobile phase is 0.1% formic acid aqueous solution -0.1% formic acid acetonitrile, with gradient elution; Electrospray positive ion mode ESI+, multi reaction monitoring MRM mode, sibutramine characteristic ion pair qualitative, external standard standard curve method quantitative, detection limit can reach ng level, high accuracy, can distinguish false positive
3. High performance liquid chromatography (HPLC): C18 reverse phase chromatography column, detection wavelength 223nm, methanol buffer salt system as mobile phase, suitable for content determination of high-purity raw material samples based on retention time comparison; The disadvantage is that matrix interference cannot be completely ruled out, and positive samples need to be confirmed by mass spectrometry review.

1. Dietary capsule formula: This product has high powder purity and good stability, and can be used for the compound production of body management capsule products. It is compatible with various nutritional excipients and suitable for industrial filling processes.
2. Tablet candy development: suitable for weight maintenance tablet formula, with good powder flowability, easy to mix and pellet for tablet pressing, meeting the large-scale production needs of health food.
3. Solid beverage powder: can be added to the formulated solid dietary powder system, with excellent compatibility, suitable for powder mixing and processing, and aimed at daily body management related products.
4. Cross border dietary supplements: adapted to overseas brand formula research and development, can provide a complete set of COA and MSDS data, meet export quality inspection and review, used for overseas weight management dietary products.
5. Compound nutritional ingredients: can be combined with plant extracts and functional nutritional components for customized health ingredient solutions, serving brand new product development.

1. 1kg/aluminum foil bag, built-in double-layer PE moisture-proof bag, vacuum sealed packaging, suitable for laboratory small-scale testing and sample making.
2. 5kg/aluminum foil bag, moisture-proof and light proof vacuum sealed, convenient for factory formula debugging and small to medium batch testing.
3. 25kg/cardboard drum, double-layer PE lined bag inside the drum, standard industrial bulk packaging, suitable for large-scale domestic stocking.
4. 25kg/UN certified export cardboard drum, meeting the requirements for sea and air transportation, suitable for 40FCL full container foreign trade export orders.
5. 100g/sample aluminum bag, independent vacuum packaging, used for customer testing and qualification inspection, with COA and MSDS data attached with the goods.

1. Normally, sealed and moisture-proof packaging is used for transportation, with full protection from light and moisture throughout the process to prevent raw materials from getting damp and deteriorating, ensuring stable quality of goods.
2. Supporting multiple logistics methods such as land and sea transportation, it can adapt to domestic bulk shipments and overseas 40FCL FCL foreign trade export business.
3. Export orders can be accompanied by a complete set of customs declaration related documents, which are synchronized with the goods and meet the requirements of customs inspection and review.
4. Strictly inspect the integrity of the packaging before loading the goods onto the vehicle, take measures to prevent compression and reduce the risk of damage and leakage during transportation.
5. We can arrange logistics solutions according to customer needs, provide freight tracking information, and facilitate customers to grasp the real-time progress of goods transportation.

1. If the packaging is found to be damaged after arrival, we will provide proof as soon as we receive the goods, and we will quickly verify and handle it to protect the rights and interests of our customers.
2. Raw materials can be sent for inspection upon receipt. If the test results do not match the COA report data issued by our company, we support negotiating a solution.
3. Our professional technical team is online to provide consultation on raw material application technology and answer questions related to formula usage.
4. Follow up on the entire order process, with real-time communication from shipment to receipt, and promptly assist in following up on any logistics issues that arise.
5. Due to quality issues with our raw materials, we can handle them according to our cooperation agreement and provide attentive pre-sales and after-sales services throughout the entire process.

1. Q: Can you guarantee the purity of this raw material?
Answer: The purity of the raw materials is stable at ≥ 99%, and each batch comes with a COA testing report, which can support third-party inspection and verification by customers.
2. Q: Can you provide a complete set of MSDS and COA documents?
Answer: Yes, after placing the order, MSDS safety instructions and COA quality inspection reports can be provided simultaneously to meet the needs of customs declaration and warehouse audit.
3. Q: What is the minimum order quantity and can we provide samples?
Answer: We support small sample testing and offer both small and large batch sizes. The specific minimum order quantity can be negotiated with our business personnel.
4. Q: What is the appearance and solubility of the raw material?
Answer: The product is a white powder with stable physical and chemical properties. It has good compatibility with most excipients and is suitable for processing in various dosage forms.
5. Q: What terminal products are suitable for?
Answer: It can be used for large health formulas such as compressed candies, capsules, solid beverages, dietary powders, etc. The terminal must comply with local regulations.
6. Q: Can customized blending and compounding of raw materials be done?
Answer: We support customized compounding solutions and can provide technical support based on customer formula requirements. We will communicate and evaluate the feasibility of the solution.
7. Q: Does logistics support export? Can we handle 40FCL full container load?
Answer: Supports domestic shipping and foreign trade export, can undertake full container load orders, and cooperate to provide the necessary customs clearance documents.
8. Q: What should I do if the goods get damp or damaged during transportation?
Answer: Please inspect the packaging on site upon receipt. If there is any damage, please provide photo evidence, and we will issue a full refund.
9. Q: How to handle inconsistencies between the received goods inspection and the report?
Answer: If there is a discrepancy between the third-party testing and our report, both parties can jointly entrust a third-party authoritative institution to review and handle it according to the cooperation agreement.

The company solemnly promises that all functional raw materials sold by our company are in compliance and legal circulation, strictly abide by national production and operation standards and import and export trade regulations, and resolutely eliminate all unqualified and non compliant raw materials from leaving the factory for circulation. Our company has been deeply involved in the research and production of functional raw materials for many years, with standardized production workshops and a complete quality inspection system. From raw material selection, purification and processing, finished product testing to warehousing and shipping, we have established a closed-loop control mechanism for the entire process, strictly controlling quality checkpoints at all levels, and ensuring the purity, stability, and safety of each batch of raw materials in all aspects.
All factory raw material batch information is complete and traceable to the source, providing customers with a complete set of compliance materials such as genuine and effective COA quality inspection reports, MSDS safety technical manuals, etc., fully meeting various usage needs such as domestic warehousing audits, third-party testing, and foreign trade customs clearance, and fully assisting customers in conducting product research and development and sales in compliance. Our company always adheres to the business philosophy of honest operation and quality-oriented, and will never falsify or forge qualification information.
If any raw materials flowing out of our company are found to have quality, compliance, or other issues related to our responsibility after being tested by authoritative institutions, the company will respond promptly, actively communicate and verify the problems, and provide exclusive solutions such as re inspection, replacement, and replenishment free of charge, fully protecting the legitimate rights and interests of every customer. At the same time, we solemnly declare that our company only provides compliant raw material supply services. Downstream customers' product formula formulation, packaging promotion, market sales and other aspects must strictly comply with local laws and regulations and operate in compliance with laws and regulations.

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