Appearance: White or off-white lyophilized powder; peptide, easily soluble in water, limited aqueous solution stability, needs low-temperature and light-protected storage (-20℃ frozen storage). Purity: API ≥99.0%; peptide impurities are core quality control items
1.Glucose-dependent promotion of insulin secretion, inhibition of glucagon release, lowering blood glucose;
2.Delays gastric emptying, acts on the hypothalamic appetite center, reduces hunger, enhances satiety, and decreases food intake;
3.Has cardiovascular benefits, reducing the risk of major adverse cardiovascular events in patients with type 2 diabetes combined with cardiovascular disease.
Product Description and Parameters
Our company specializes in Semaglutide raw material, which is a peptide GLP-1 receptor agonist, CAS: 910463-68-2. The product purity is stable, and complete quality inspection documents such as COA and MSDS can be provided, supporting bulk supply and foreign trade export. The raw material adopts mature synthesis technology with controllable impurities and good stability, mainly used in fields such as pharmaceutical R&D and preparation development. The company strictly controls full-process quality testing, possesses stable production capacity, and supports flexible packaging to match the procurement needs of domestic and foreign customers. Relying on years of import and export experience, we can efficiently arrange logistics delivery and provide professional pre-sales consultation and after-sales technical support. We adhere to quality standards, serve global customers with stable supply sources and competitive prices, and continuously provide reliable raw material solutions in the field of peptide APIs.
Parameters
| Name | Semaglutide |
| CAS No. | 910463-68-2 |
| Chemical Name | Nε26-[(S)-(22,40-dicarboxy-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazatetracontan-1-oyl)][Aib⁸,Arg³⁴] GLP‑1-(7‑37) |
| Molecular Weight | 4113.58 Da |
| Appearance | White to off-white lyophilized powder |
| Solubility | Easily soluble in water and dilute acetic acid; insoluble in organic solvents |
| Aqueous Solution | Clear and colorless; 1mg/mL aqueous solution pH |
| Specific Optical Rotation [α]²⁰ᴰ | +12.0° ~ +15.0° (c=1, DMF) |
| Hygroscopicity | Possesses hygroscopicity; must be sealed to protect from moisture |
| Existing Form | Acetate peptide (regular supply) |
| LC-MS | Molecular weight matches theoretical value ±1 Da |
| RP-HPLC | Retention time is consistent with the reference standard |
| FTIR | Spectrum matches the standard sample |
| Main Content | ≥98.0%, high-end batches ≥99.0% |
| Single Maximum Impurity | ≤0.50% |
| Total Related Substances | ≤2.0% Water Content (KF Karl Fischer) |
| Assay | 98.0~102.0% (External standard method) |
| High Molecular Aggregates (SEC-HPLC) | ≤0.5% |
| Bacterial Endotoxins (LAL) | ≤50 EU/mg; injectable grade can achieve ≤5 EU/mg |
| Microbial Limit | Total aerobic microbial count ≤100 CFU/g, no pathogenic bacteria |
| Target | GLP-1 receptor agonist |
| Plasma Protein Binding Rate | >99% (bound to albumin) |
| Elimination Half-Life | About 7 days (long-acting, once-weekly administration) |
| Apparent Volume of Distribution | About 12.4 L |
| Clearance Rate | About 0.05 L/h |
| Bioavailability (Subcutaneous) | About 89% |
What is the Effect of Semaglutide?
1.Targets the appetite center in the brain, suppresses hunger signals, and significantly reduces the impulsive craving for sweets and high-calorie foods.
2.Delays the rate of gastric emptying, maintains a long-lasting feeling of fullness, and naturally reduces eating frequency and main meal intake.
3.Prioritizes the consumption of visceral abdominal fat, reducing deep fat that harms metabolism, rather than simple water loss.
4.Weakens the food reward effect, relieves binge eating tendencies, and helps establish a stable and healthy eating pattern.
5.Regulates metabolism in a glucose-dependent manner, resulting in a low risk of hypoglycemia during fat loss, making weight reduction smoother and safer.
6.Regulates lipid metabolism levels and lowers triglycerides, improving multiple metabolic indicators while reducing fat.
7.Binds to albumin in a long-acting manner, maintaining a long action cycle in the body, continuously suppressing appetite, and maintaining long-term fat loss effects.
8.Reduces body inflammation levels, relieves chronic metabolic stress induced by obesity, and assists in continuous weight management.
Product Application Fields
1.R&D of weight loss preparations for obese and overweight populations, used for long-acting fat loss injection formulation development.
2.Metabolic syndrome-related research, used for scientific research trials targeting metabolic problems such as hyperlipidemia and abdominal obesity.
3.Type 2 diabetes drug development, researching peptide preparations with dual efficacy of blood glucose reduction and weight management.
4.Innovation product R&D for dietary weight management, using research-grade active raw materials for efficacy evaluation experiments.
5.Exploration of pharmacological mechanisms, conducting animal and cell experiments related to GLP-1 receptor pathways and appetite regulation.
6.Development of new dosage forms, including cutting-edge formulation research on sustained-release preparations and peptide delivery systems.
Why Choose Us
Our company is deeply engaged in the field of peptide API import and export, mainly specializing in Semaglutide raw material, and is a trustworthy supplier. We strictly control product quality, and the purity of raw materials is stable. Each batch can be provided with complete COA, MSDS, HPLC, and LC-MS testing reports. All indicators meet research preparation R&D standards; the impurity system is controllable, and batch-to-batch consistency is strong, reducing the risks of customer experiments and formulation development.
We possess a stable production capacity reserve, supporting flexible supply from lab-scale samples to bulk orders. Packaging specifications can be customized as needed, adapting to different procurement requirements of research institutions and preparation R&D enterprises. Relying on years of foreign trade import and export experience, we are familiar with cross-border logistics processes, allowing us to efficiently arrange goods delivery, ensure low-temperature storage requirements for peptide raw materials during transportation, and guarantee that product activity is not damaged.
Equipped with a professional technical team, we provide pre-sales product parameter consultation and after-sales technical support services, quickly responding to customer inquiries. We adhere to serving global customers with highly competitive prices, stable supply sources, and efficient services. Strictly abiding by compliance baselines, products are limited to scientific research and R&D purposes, assisting customers in quickly advancing the development of GLP-1-related preparations, weight loss, and metabolic projects, making us your reliable partner for peptide raw material procurement.
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