Triamcinolone Acetonide (CAS No. 76-25-5) is a white powder with a purity of 99%. It is an organic compound with the molecular formula C24H31FO6. Primarily used as an adrenocortical agent, it is indicated for the treatment of various skin disorders and for relieving discomfort associated with oral ulcers.
Our company specializes in the supply of Triamcinolone Acetonide pharmaceutical raw materials. This product is a medium- to high-potency glucocorticoid with anti-inflammatory and immunosuppressive activities. The raw material is supplied as a white to off-white crystalline powder, featuring high HPLC assay purity, stringent control of related substances, consistent batch-to-batch quality, and excellent powder properties. It is suitable for the development of various topical formulations.
Regular stock is available. We support sample testing, pilot-scale trials, and bulk procurement. Supporting documentation, including COAs and MSDSs, can be provided. We also support international import and export operations, delivering a stable and reliable supply of raw materials to pharmaceutical formulation developers and research institutions worldwide.
Product Description and Specifications
Triamcinolone Acetonide is the acetonide derivative of triamcinolone and is classified as an intermediate-potency glucocorticoid. Its pharmacological effects are similar to those of triamcinolone, including anti-inflammatory, antipruritic, and vasoconstrictive activities. It has minimal effects on sodium and water retention, while its anti-inflammatory activity is relatively potent and long-lasting.
The anti-inflammatory activity of 4 mg of Triamcinolone Acetonide is approximately equivalent to that of 5 mg of prednisolone or 20 mg of hydrocortisone.
Triamcinolone Acetonide is a long-acting adrenocortical corticosteroid. Its mechanism of action is similar to that of triamcinolone, producing anti-inflammatory, antipruritic, and vasoconstrictive effects. Its anti-inflammatory and antiallergic activities are potent and prolonged, with a potency approximately 20–30 times greater than that of cortisone.
Triamcinolone Acetonide exerts anti-inflammatory, antipruritic, and vasoconstrictive effects, with relatively potent and sustained anti-inflammatory and antiallergic activity. For dermatitis and other skin disorders, it can be administered through topical application or occlusive dressing techniques, allowing absorption through the skin. Triamcinolone Acetonide is generally very well tolerated when used topically.
|
Parameter |
Specification |
|
English Name |
Triamcinolone Acetonide |
|
Assay |
≥99% |
|
Molecular Formula |
C24H31FO6 |
|
Molecular Weight |
434.498 |
|
CAS Number |
76-25-5 |
|
Density |
1.33g/cm3 |
|
Melting Point |
274-278℃ |
|
Boiling Point |
576.9ºC |
|
Flash Point |
302.7ºC |
|
Refractive Index |
1.589 |
|
Appearance |
White to off-white crystalline powder |
|
Molar Refractivity |
109.41 |
|
Molar Volume (cm3/mol) |
324.8 |
|
Isotonic Specific Volume (90.2K) |
882.9 |
|
Surface Tension (dyne/cm) |
54.5 |
|
Polarizability (10 -24cm 3) |
43.37 |
|
Calculated Hydrophobic Parameter (XlogP) |
None |
|
Hydrogen Bond Donor Count |
2 |
|
Hydrogen Bond Acceptor Count |
7 |
|
Rotatable Bond Count |
2 |
|
Tautomer Count |
9 |
|
Topological Polar Surface Area |
93.1 |
|
Heavy Atom Count |
31 |
|
Formal Charge |
0 |
|
Complexity |
925 |
|
Isotope Atom Count |
0 |
|
Defined Atom Stereocenter Count |
8 |
|
Undefined Atom Stereocenter Count |
0 |
|
Defined Bond Stereocenter Count |
0 |
|
Undefined Bond Stereocenter Count |
0 |
What Are the Main Functions of Triamcinolone Acetonide?
Local Anti-Inflammatory Activity
Triamcinolone Acetonide is an intermediate-potency glucocorticoid API. It reduces vascular permeability, inhibits the release of inflammatory mediators, alleviates local tissue edema, and helps mitigate inflammation-related responses.
Immunomodulatory and Immunosuppressive Effects
It interferes with immune cell activation, suppresses excessive local immune responses, and reduces tissue damage associated with immune-mediated reactions.
Antiproliferative Effects
It inhibits abnormal proliferation of epidermal cells and slows tissue hyperplasia, making it suitable for research and development studies involving topical pharmaceutical formulations.
Application Areas of Triamcinolone Acetonide
Development of Topical Formulations
Used as an active pharmaceutical ingredient in the formulation development of topical corticosteroid suspensions, creams, ointments, and other dosage forms. Applications include formulation compatibility screening, preliminary development of generic drugs, and process scale-up studies.
Pharmacological Research and Analytical Testing
Supplied for pharmacological studies conducted by research institutions, particularly in the areas of local inflammation and tissue proliferation. It is also suitable for related-substance profiling, pharmacopoeial analytical method development, and long-term stability studies of pharmaceutical formulations.
International Supply of Pharmaceutical Raw Materials
We provide Triamcinolone Acetonide API for international export to pharmaceutical research and development companies. Supporting R&D services can also include the preparation of impurity reference standards and customized small-batch synthesis.
Quality Control and Analytical Testing of Triamcinolone Acetonide
Our Triamcinolone Acetonide raw material features consistent physicochemical properties and batch-to-batch stability. Assay is determined using high-performance liquid chromatography (HPLC), with product purity maintained at not less than 99.0%.
Related substances are subject to stringent quality control, with strict limits established for both individual impurities and total impurities.
The analytical procedure employs a C18 reversed-phase chromatographic column, ultraviolet (UV) detection, and external standard quantification.
A comprehensive quality control program is also conducted, covering appearance identification, loss on drying, heavy metals, residue on ignition, and other relevant testing parameters.
Each batch undergoes independent quality inspection, and a Certificate of Analysis (COA) is issued accordingly. All analytical data are accurate and reliable. Our products meet pharmacopoeial requirements and are suitable for the quality assessment standards applicable to pharmaceutical formulation development and international export.
Packaging and Transportation of Triamcinolone Acetonide
Product Packaging
Samples are hermetically sealed in vacuum-packed aluminum foil bags to prevent exposure to oxygen and moisture and preserve the sample's physicochemical properties.
Industrial bulk quantities are packed in double-layer polyethylene (PE) inner bags and secured in reinforced 25 kg fiberboard drums for protection against physical damage, dust, and moisture.
Customized packaging specifications are available upon request. Each package is inspected for sealing integrity before dispatch to eliminate the risk of leakage.
Logistics and Transportation
Domestic shipments are transported under ambient-temperature conditions. Handling procedures are designed to prevent impact, prolonged exposure to direct sunlight, and water ingress.
For international export orders, pallet securing and stretch-film wrapping can be arranged to enhance protection during long-distance ocean freight and reduce the risk of damage during cross-regional transportation.
After-Sales Service
1. Quality Assurance and After-Sales Support
Every batch undergoes comprehensive quality inspection before release to ensure that the actual test results are consistent with the corresponding COA documentation.
If customers are dissatisfied with product quality after receipt, they may submit supporting test documentation within the agreed period. Upon verification, we offer a full refund and arrange for our technical personnel to conduct a further review and assessment.
2. Logistics and Delivery Support
In-stock orders can be dispatched on the same day. We provide shipment tracking and monitor logistics progress throughout the delivery process.
In the event of cargo loss during transportation, full compensation will be provided. Export shipments are reinforced with moisture-resistant protective packaging in advance to minimize potential damage during long-distance transportation.
3. Technical Support
We provide technical assistance and consultation on raw material storage conditions, pharmaceutical formulation development, and related technical matters.
Our team responds promptly to customer inquiries and addresses order-related issues in a timely manner, providing pharmaceutical research and development customers worldwide with reliable raw material procurement support and a hassle-free purchasing experience.
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