Fluocinolone Acetonide API (CAS No. 67-73-2)

Fluocinolone Acetonide API (CAS No. 67-73-2)

Fluocinolone Acetonide, also known as Fluocinolone, has CAS No. 67-73-2, a molecular formula of C₂₄H₃₀F₂O₆, and a molecular weight of 452.488. It is a topical glucocorticoid.

Product Introduction

Fluocinolone Acetonide, also known as Fluocinolone, has CAS No. 67-73-2, a molecular formula of C₂₄H₃₀F₂O₆, and a molecular weight of 452.488. It is a topical glucocorticoid.

With its anti-inflammatory, antiallergic, and antipruritic properties, Fluocinolone Acetonide is used to treat various pruritic and non-infectious inflammatory skin conditions, including contact dermatitis, atopic dermatitis, seborrheic dermatitis, eczema, pruritus, psoriasis, neurodermatitis, and discoid lupus erythematosus. It is commonly formulated as a 0.025% ointment or cream for topical application, typically 3–4 times daily. It is contraindicated for fungal and viral skin infections and cutaneous tuberculosis. Prolonged use may cause skin atrophy and telangiectasia.

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Product Description and Specifications

 

Fluocinolone Acetonide is a potent fluorinated glucocorticosteroid active pharmaceutical ingredient (API). It is a white crystalline powder with strong anti-inflammatory and antipruritic properties. It is primarily used in topical dermatological formulations for human use, including ointments and medicated patches, as well as veterinary anti-inflammatory preparations. The product is classified as general cargo for export, with comprehensive after-sales support available.

 

Parameter

Specification

English Name

Fluocinolone Acetonide

Synonyms

Fluocinolone Acetonide, Synalar, Fluocinolone Acetate

CAS No.

67-73-2

Assay

99%

Molecular Formula

C24H30F2O6

Molecular Weight

452.4882

Density

1.36 g/cm³

Melting Point

267–269°C

Boiling Point

578.5°C at 760 mmHg

Flash Point

303.7°C

Vapor Pressure

8.57E-16 mmHg at 25°C

Shelf Life

24 months

Analytical Method

Liquid Chromatographic Analysis

Storage Conditions

Protect from light; store in a cool, dry place

 

Product Functions and Mechanism of Action

 

Fluocinolone Acetonide provides potent anti-inflammatory, antiallergic, and antipruritic effects. Its pharmacological actions include vasoconstriction and inhibition of epidermal proliferation. It stabilizes lysosomal membranes, reduces capillary permeability, decreases inflammatory exudation, and inhibits the release of histamine and other allergic and inflammatory mediators, thereby delivering strong anti-inflammatory and antipruritic effects.

 

Application Fields

 

1. Pharmaceutical API and Topical Dermatological Formulation Ingredient: Used as a raw material in creams, ointments, gels, medicated patches, and topical liniments. Suitable for formulations targeting non-infectious, thickened and pruritic skin conditions, including allergic dermatitis, chronic eczema, neurodermatitis, psoriasis, and prurigo nodularis.

2. Combination Formulations: Can be combined with antibiotics, borneol, vitamin B6, and other ingredients to develop compound ointment formulations.

3. Veterinary Applications: Used as an active ingredient in topical veterinary anti-inflammatory and antipruritic preparations.

4. Pharmaceutical Research and Development: Used as an intermediate in pharmaceutical R&D and steroid formulation process research.

 

Product Packaging and Transportation

 

- Sample Packaging: 10 g, 50 g, 100 g, and 500 g in amber glass bottles or vacuum-sealed aluminum foil bags.

- Standard Export Packaging: 1 kg vacuum-sealed aluminum foil bags, 5 kg aluminum containers, and 25 kg fiber drums (with an inner PE sealing bag for protection against light and moisture). Customized shipping marks and English-language labels are available upon request.

- Cargo Classification: General cargo. Sea, air, road, and rail transportation are supported.

- Transportation Requirements: Protect from light and rain, and avoid prolonged exposure to high temperatures and direct sunlight. Do not ship together with strong oxidizing agents or food products.

- Storage Conditions: Keep tightly sealed and protected from light. Refrigerate at 2–8°C. Shelf life: 24 months.

 

After-Sales Service

 

We are committed to providing a comprehensive after-sales service system to safeguard our customers' purchasing interests.

A complete set of documentation, including the Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS), is provided with each shipment. All products are supplied in strict accordance with the specifications and quality parameters stipulated in the contract.

If incoming inspection or testing confirms that the product fails to meet the agreed specifications, we will provide a full refund or free replacement shipment following verification.

We also provide end-to-end logistics tracking. In the event of confirmed cargo damage or loss during transportation, we will promptly arrange compensation or reshipment.

Our customer service team is available 24 hours a day to respond to inquiries and provide technical assistance regarding product storage, formulation, and use, ensuring that any issues are addressed promptly and professionally.

Important Notice: Product abnormalities resulting from improper storage or operational errors on the customer's part are not covered by our after-sales compensation policy.

We are dedicated to delivering reliable products and attentive service at every stage of the purchasing process, ensuring a smooth and worry-free procurement experience.

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