High-Quality Tadalafil Raw Material Supply (CAS 171596-29-5)

Under sexual stimulation, Tadalafil triggers the release of nitric oxide in the body, increasing the concentration of cGMP in the corpus cavernosum. Tadalafil inhibits PDE5, reduces cGMP degradation, relaxes the smooth muscle of the penile corpus cavernosum, dilates blood vessels, and increases blood flow to the corpus cavernosum, helping patients with erectile dysfunction obtain and maintain an erection. It takes effect 1 hour after administration.

At the same time, it can relax prostate and bladder smooth muscles to improve lower urinary tract symptoms of benign prostatic hyperplasia; it can also dilate pulmonary blood vessels and reduce pulmonary vascular resistance for use in pulmonary arterial hypertension.

Our company professionally produces and sells Tadalafil active pharmaceutical ingredient (API), stably supplying domestic and foreign pharmaceutical enterprises, R&D institutions, and foreign trade customers for the long term. This product is a long-acting phosphodiesterase type 5 (PDE5) inhibitor. The raw material has high purity and strictly controlled impurities. Each batch is accompanied by a complete COA quality inspection report, with stable quality that meets the standards for formulation production and scientific research use. Under sexual stimulation, Tadalafil can relax the smooth muscle of the penile corpus cavernosum and increase local blood flow. It is used in erectile dysfunction formulations and can also be used in drug R&D related to benign prostatic hyperplasia and pulmonary arterial hypertension. The drug effect is long-lasting and unaffected by food intake. As a first-hand supplier, we can supply sufficient quantities and accept both large and small orders, with outstanding cost performance. Regular packaging uses 25 kg fiber drums for sealed packaging, and small samples can be sub-packaged in aluminum foil vacuum bags. Domestic freight transportation can be arranged, and foreign trade supports sea freight and air freight, with complete export documents.

1.Tadalafil belongs to the selective phosphodiesterase type 5 (PDE5) inhibitors, mainly used for the development of formulations related to erectile dysfunction.

2.Under the action of sexual stimulation, it inhibits PDE5 enzyme activity, reduces cGMP degradation, and relaxes the smooth muscle of the penile corpus cavernosum.

3.Dilates corpus cavernosum blood vessels, increases local blood flow, and helps obtain and maintain an erection of sufficient hardness.

4.Relaxes prostate and bladder smooth muscles, improving lower urinary tract symptoms such as frequent urination and difficulty in urination caused by benign prostatic hyperplasia.

5.Dilates pulmonary blood vessels, reduces pulmonary vascular resistance, and is used for the R&D of pulmonary arterial hypertension formulations to improve patients' exercise tolerance.

6.The drug itself does not stimulate sexual desire and must take effect under sexual stimulation conditions, only improving the physiological engorgement process of erection.

1. Production of pharmaceutical preparations: Used to manufacture tadalafil tablets for the treatment of erectile dysfunction in men.

2. Research and development for benign prostatic hyperplasia (BPH): Developing formulations to alleviate lower urinary tract symptoms, such as frequent urination and difficulty in urinating.

3. Research and development for pulmonary arterial hypertension (PAH): Creating formulations designed to reduce pulmonary vascular resistance and improve exercise tolerance in patients.

4. Pharmaceutical research and experimentation: Serving as a raw material for *in vitro* and *in vivo* pharmacological and toxicological studies.

5. Laboratory reference standard: Used for assaying drug content, detecting related substances, and validating analytical methods.

6. Import and export of active pharmaceutical ingredients (APIs): Supplied to domestic and international pharmaceutical companies; also utilized in the development of formulations and manufacturing processes for generic drugs.

1.The main content of Tadalafil API raw material is ≥99.0%, tested by High-Performance Liquid Chromatography (HPLC), with stable and reliable indicators.
2.Single impurities and total impurities are strictly controlled within low limits, meeting quality requirements for pharmaceutical raw materials.
3.Items such as water content, residue on ignition, heavy metals, and residual solvents are strictly managed, with all physical and chemical indicators meeting standards.
4.Each batch of products is accompanied by a COA quality inspection report, with complete purity-related testing data and minimal batch-to-batch variation.

1.Appearance: Visually observe sample appearance, color, and crystalline form, checking physical and chemical properties.
2.Identification: Infrared Spectroscopy (IR) and HPLC retention time comparison methods are used for qualitative identification of samples.
3.Assay Determination: High-Performance Liquid Chromatography (HPLC) external standard method is used to measure the active ingredient content of Tadalafil.
4.Related Substances: High-Performance Liquid Chromatography (HPLC) is used to detect individual impurities and total impurities, controlling impurity limits.

1.Regular bulk goods adopt 25kg fiber drum packaging, inner layer double-layer PE sealed bags, built-in desiccant, effectively moisture-proof and oxidation-proof.
2.Samples use aluminum foil vacuum bags for sealed packaging, isolating air and water vapor to ensure raw material storage stability.
3.Customized sub-packaging specifications can be provided according to customer needs, with product name, batch number, and specifications clearly marked on the drum body.
4.Outer packaging is reinforced with buffer protection before leaving the warehouse to reduce damage caused by transport compression and collision.
5.Domestic orders select room-temperature dedicated line freight transport, with full-process protection against rain, sun exposure, and moisture, and goods are trackable.
6.Foreign trade orders support sea freight and air freight, equipped with complete customs declaration documents to assist customers in customs clearance.
7.Orders are rapidly scheduled for shipment after confirmation, synchronizing logistics information promptly to facilitate customers in tracking shipment status.
8.Product quantity and batch numbers are re-checked before shipment to ensure accurate delivery product information.

Our company has a comprehensive after-sales service system. Products undergo strict quality inspection before leaving the warehouse, with a COA quality inspection report. After receiving the goods, if customers have questions regarding product quality or packaging, they may contact us at any time, and our team will quickly respond to check batch-related testing data. Technical consultation related to the product can be provided to answer various technical questions regarding formulation and testing. In case of abnormal situations such as transport damage, we communicate and negotiate solutions promptly after customers provide relevant proof. Orders are followed up throughout the process, synchronizing logistics and delivery date information. We value every customer's request, adhere to honest management, make every effort to protect customer procurement rights and interests, and are committed to establishing long-term, stable, and mutually beneficial cooperative relationships with customers.

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