Sibutramine 106650-56-0 Appearance: White crystalline powder, purity above 99%. An appetite-suppressant raw material that mildly regulates appetite, reduces emotional snacking and binge eating, extends satiety, delays gastric emptying, stabilizes blood sugar levels, helps reduce excess calorie intake, creates a reasonable calorie deficit, and provides auxiliary support for fat loss and slimming. It is suitable for weight-loss groups who struggle with appetite control, have strong cravings, or frequently eat extra snacks. Combine it with a reasonable diet and exercise to maintain a healthy fat-loss rhythm. Safe and controllable, it helps manage food intake and mildly assists weight management.
Product Description & Parameters
Sibutramine chemical name: (±) N-{1-[1-(4-chlorophenyl) cyclobutyl]-3-methylbutyl}-N,N-dimethylamine hydrochloride, CAS No.: 106650-56-0, Molecular Formula: C₁₇H₂₆ClN. As an appetite suppressant, it enhances satiety and reduces food intake by inhibiting the reuptake of serotonin and norepinephrine. At the same time, it promotes thermogenesis and increases energy expenditure, achieving weight loss through dual pathways. This product features high purity with content above 99%, stable batch consistency, sufficient stock, and fast shipment. Under strict quality control, every batch undergoes internal testing. Free samples can be provided for customer formulation tuning and verification. Shipments are accompanied by a COA (Certificate of Analysis) test sheet and authoritative third-party testing reports, with heavy metals, microorganisms, and assay specifications strictly controlled. It supports foreign trade export with optional packaging specifications, complete export documentation, mature logistics channels, stable delivery times, and prompt after-sales response, perfectly adapted for bulk procurement by overseas manufacturers.
Parameters
| Name | Sibutramine |
| Synonyms | N-(1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutyl)-N,N-dimethylamine |
| Molecular Formula | C17H26ClN |
| Molecular Weight | 279.85 |
| Appearance | White crystalline powder |
| CAS Registry Number | 106650-56-0 |
| Melting Point | 191 to 192 ℃ |
| Boiling Point | 342.6 ℃ |
| Flash Point | 161 ℃ |
| Solubility | Highly soluble in methanol and ethanol; soluble in water; slightly soluble in acetone; practically insoluble in n-hexane. |
| Acidity/Alkalinity | Hydrochloride aqueous solution is slightly acidic |
| Optical Activity | Racemate (±), clinical use of racemic mixture |
| Assay | (HPLC) ≥98.0% (Standard / Analytical Grade) |
| Loss on Drying | Meets water content requirements for monohydrate (approx. 5.4%) |
| Heavy Metals | ≤10 ppm |
| Residue on Ignition | ≤0.1% |
| Related Substances | Single impurity ≤0.5%, total impurities ≤1.0% |
| Testing Methods | HPLC (External standard method); UV Spectrophotometry |
| Storage Conditions | Sealed, protected from light, kept in a dry place; analytical standards recommended for refrigeration at 2–8℃ |
| Packaging Specifications | (Standard sample) Commonly in 50mg, 100mg, 1g, 5g vials |
| Transportation Requirements | General chemical shipment, moisture-proof and sun-proof |
| Shelf Life | 24 months |
What is the Mechanism and Function of Sibutramine?
Enhancing Satiety
Sibutramine inhibits serotonin reuptake and acts on the hypothalamic appetite center to amplify satiety signals, delay the onset of hunger, reduce cravings for sweets and high-calorie foods, minimize mindless snacking and extra meals, proactively decrease total food intake, and control calorie intake.
Promoting Lipolysis
Sibutramine elevates norepinephrine levels in the body and activates lipolytic pathways in adipose cells, promoting the breakdown of stored triglycerides into fatty acids for systemic oxidation and utilization, reducing continuous fat accumulation, and assisting in the consumption of excess body fat.
Regulating Energy Balance
It simultaneously regulates both intake and expenditure sides-reducing food intake while increasing energy expenditure-breaking the original calorie surplus, establishing a calorie deficit, altering body energy storage patterns, and gradually achieving weight reduction.
Suppressing Appetite and Food Cravings
In addition to physiological hunger, it can weaken emotional eating impulses, relieve cravings triggered by stress or boredom, help users stick to diet management more easily, and reduce recurrent binge eating.
Product Application Fields
Pharmaceutical Industry
Can be used as a weight-loss drug intermediate for formulation research and development of obesity treatment preparations.
Overseas Health Food / Supplements
Supplied to overseas dietary supplement factories to develop finished weight-loss products compliant with local regulations.
Scientific Research & R&D
Supplied to laboratories and research institutes for formula debugging and experimental trials in metabolism and weight management directions.
Product Purity & Quality Control
1.Raw materials are refined using advanced synthesis processes, yielding high purity, stable HPLC assay content, and minimal batch-to-batch variation. The entire production process is strictly controlled-from raw material feeding, reaction synthesis, to purification and crystallization-effectively reducing impurities such as related substances, heavy metals, and residual solvents.
2.Every batch of product undergoes internal laboratory self-inspection before leaving the factory and is supplied with a matching COA report. Authoritative third-party inspection certificates can be provided upon request, with all indicators meeting export quality control standards. Microbial limits are strictly managed to guarantee raw material cleanliness, adapting to high-demand scenarios such as pharmaceutical intermediates and dietary supplements.
3.Stable warehousing conditions, sealed and light-proof storage, resistant to moisture and deterioration, ensuring controllable long-term storage quality. Sample testing is supported, allowing pre-shipment parameter verification. Large-batch supply features strong quality consistency, reducing the risk of finished product formula fluctuations.
Product Testing Methods
1.Assay Testing: High-Performance Liquid Chromatography (HPLC), external standard method quantitative analysis to determine main active ingredient content.
2.Related Substances: High-Performance Liquid Chromatography, controlling single impurity and total impurity limits.
3.Heavy Metals Testing: Inductively Coupled Plasma Mass Spectrometry (ICP-MS), testing for lead, arsenic, mercury, cadmium, etc.
4.Loss on Drying: Constant temperature vacuum drying method to test moisture content and evaluate storage stability.
5.Residue on Ignition: Muffle furnace high-temperature ignition method to determine inorganic ash impurities.
6.Microbial Testing: Plate count method, testing total plate count, molds, yeasts, and pathogenic bacteria.
Product Packaging
1.Standard Packaging: Aluminum foil bag sealed packaging with moisture-proof and light-shielding inner layer, suitable for samples and small trial batches, convenient for sampling and testing.
2.Bulk Packaging: Fiber drum packaging with built-in double-layer PE inner bags, strong sealing, pressure-resistant and damage-proof, suitable for large-volume foreign trade shipments.
3.Customized Service: Packaging specifications, label information, and matching shipping marks can be customized according to customer requirements to meet sea and air freight export standards.
Product Transportation
1.Flexible transport methods, supporting sea freight, air freight, and international express channels, which can be reasonably arranged according to delivery timeline and cost requirements.
2.Comprehensive moisture-proof, light-shielding, and shock-proof protection throughout the journey; cargo information is traceable with real-time updates on logistics status.
3.Familiar with foreign trade export procedures, complete documentation, assisting with customs clearance, properly handling transportation anomalies, and minimizing risks of cargo damage or lost packages.
After-Sales Service
1.Quality Guarantee: Bulk goods are delivered strictly in accordance with sample specifications, accompanied by a COA report. Quality discrepancies can be negotiated and handled. For example, if the customer tests the batch raw material and the assay content does not match the agreed standard, upon providing test evidence, we will promptly arrange re-testing or product replacement.
2.Logistics After-Sales: Full tracking of cargo dynamics. In case of packaging damage or lost items, we support coordinated compensation claims. For example, if outer packaging is damaged or inner material gets damp during sea transit, or if express delivery loses a package, claims or reshipments will be conducted as agreed upon verification.
3.Technical Support: Providing technical support related to storage, testing, and formulation applications, answering customer queries promptly. For example, if a customer is unclear about addition ratios during formula debugging or HPLC test conditions, we arrange technical personnel to provide guidance.
FAQ
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