
Furosemide, CAS No. 54-31-9, is an organic compound with the chemical formula C12H11ClN2O5S. It is a potent diuretic mainly used to treat edema caused by heart, liver, kidney, and other diseases. As a potent loop diuretic, it inhibits the reabsorption of sodium and chloride in the thick ascending limb of the renal loop of Henle, increasing the excretion of water, sodium, potassium, calcium, and magnesium. The diuretic effect takes effect quickly with a relatively short duration of action. Oral administration takes effect within 30 to 60 minutes.
Product Parameters
| Chemical Formula | C12H11ClN2O5S |
| Molecular Weight | 330.744 |
| CAS No. | 54-31-9 |
| EINECS No. | 200-203-6 |
| Density | 1.606 g/cm3 |
| Melting Point | 220°C (Decomposition) |
| Boiling Point | 582.1ºC |
| Flash Point | 11 °C |
| Appearance | White crystalline powder |
| Solubility | Soluble in acetone, methanol, and dimethylformamide; slightly soluble in ethanol; insoluble in water |
| Molar Refractivity | 75.76 |
| Molar Volume (cm3/mol) | 205.8 |
| Parachor (90.2K) | 606.2 |
| Surface Tension (dyne/cm) | 75.2 |
| Polarizability (10^-24 cm^3) | 30.03 |
| Hydrophobic Parameter Reference Value (XlogP) | None |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Chemical Bond Count | 5 |
| Tautomer Count | 4 |
| Topological Polar Surface Area | 131 |
| Heavy Atom Count | 21 |
| Surface Charge | 0 |
| Complexity | 481 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalent Bond Unit Count | 1 |
Product Effects
Furosemide is a potent loop diuretic API raw material. Its core mechanism of action is inhibiting the reabsorption of sodium and chloride ions in the thick ascending limb of the renal loop of Henle, significantly increasing the excretion of water and electrolytes. It features rapid onset of diuretic action and high intensity. Oral administration takes effect in about 30 minutes, intravenous injection takes effect within several minutes, and the drug effect lasts for 4 to 6 hours. Clinically, it is mainly used to treat various edematous diseases, such as edema caused by heart failure, kidney disease, and liver cirrhosis. It can also be used for emergency treatment of hypertensive emergencies, hyperkalemia, and hypercalcemia, and can accelerate the excretion of certain toxins through urine via forced diuresis.

Product Application Fields

Active Pharmaceutical Ingredient (API)
Used for the production of Furosemide tablets and injection preparations, serving as a potent loop diuretic raw material.
Edema Disease Treatment
Used for formulation development targeting various types of edema and ascites caused by heart failure, liver disease, and kidney disease.
Hypertensive Emergency Medication
Used for preparing antihypertensive auxiliary drugs applied in hypertensive crisis scenarios accompanied by renal insufficiency.
Packaging Methods and Logistics
1.Samples are packaged in sealed aluminum foil bags, with flexible specification options available, light-proof and moisture-proof, satisfying customers' lab-scale testing requirements.
2.Bulk goods use fiber drums lined with polyethylene inner film bags, standard 25 kg/drum, with strong sealing performance to prevent leakage.
3.The drum body is printed with the product name, CAS No., batch number, production date, and relevant safety warning signs.
4.Domestic orders can choose dedicated line logistics or full truckload transport, offering stable timeliness and delivery to designated locations.
5.Foreign trade orders support sea freight and air freight, and can undertake various international trade terms such as FOB and CIF.
6.Full protection is provided throughout transport to avoid sun exposure, rain, and heavy pressure, reducing the risk of moisture and damage.
7.Documents such as COA, contracts, and customs declaration materials are fully provided before shipment to facilitate customers in completing customs clearance and warehousing inspection.
8.Logistics information is pushed promptly after shipment to track the transport status of goods in real time.
Product After-sales Service
1.Quality inspection is completed for all product batches before leaving the warehouse, with the corresponding batch COA test report attached to the shipment.
2.Within 7 working days after receipt, if customers encounter packaging damage or quantity shortages, they can provide proof to apply for verification.
3.Upon receiving quality objections, technical personnel connect immediately to assist in re-checking samples and testing data.
4.Provide technical consultation regarding product physical and chemical properties, storage, and application to answer technical questions from customers.
5.Re-inspection services for samples are supported, and both parties may agree on a third-party testing agency for quality arbitration.
6.If it is confirmed to be our quality issue, replenishment or replacement plans will be negotiated to protect customer rights.
7.Problems caused by improper storage, operation errors, or non-compliant use by customers are not within the scope of after-sales service.
8.This product is a pharmaceutical raw material and does not support returns or exchanges without a valid reason. Please confirm your procurement requirements before placing an order.
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