Sibutramine 106650-56-0 primarily functions through its metabolites, M1 and M2, which inhibit the reuptake of serotonin and norepinephrine at the presynaptic membrane, with a minor effect on dopamine reuptake. By increasing the concentration of these neurotransmitters, it enhances the feeling of satiety and reduces food intake. Simultaneously, it slightly boosts the basal metabolic rate and promotes thermogenesis, thereby facilitating weight loss. It does not act as a monoamine oxidase inhibitor and exhibits no significant anticholinergic or antihistaminic effects. This ingredient effectively delays the onset of hunger and diminishes the craving for high-calorie foods. By promoting a reduction in total caloric intake through a gentle mechanism, it is well-suited for use in dietary supplement formulations-ideally in conjunction with a healthy diet-to support weight management. Our company exports this raw material to markets across Europe, the Americas, and Southeast Asia. Our products meet international standards, and we provide full documentation for customs clearance, including COA and MSDS. We offer established cross-border logistics solutions, support the export of bulk shipments, and can assist overseas clients with product registration. With consistent quality, our raw materials empower international brands to develop health products focused on weight management.

Product Description and Specifications
Our company specializes in the R&D and large-scale production of Sibutramine 106650-56-0, an active ingredient used in weight management products. We operate standardized production facilities and maintain a comprehensive quality control system, ensuring rigorous oversight throughout the entire process-from raw material selection and extraction to final product testing. Every batch undergoes multiple quality inspection stages, guaranteeing stable active ingredient content, high purity, and low impurity levels. We provide a COA for each batch and welcome third-party verification. Committed to consistent quality, we supply reliable, high-grade weight-loss ingredients to pharmaceutical manufacturers and product formulators both domestically and internationally. With readily available stock and efficient delivery, we support both sample requests and bulk exports. We prioritize quality above all else and look forward to achieving mutual success with our global partners.
Parameters
| Alias | N-(1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutyl)-N,N-dimethylamine |
| Name | Sibutramine |
| CAS Number | 106650-56-0 |
| Molecular Formula | C17H26ClN |
| Molecular Weight | 279.85 |
| Exact Mass | 279.175 |
| PSA | 3.24 |
| LogP | 4.738 |
| Physicochemical Properties | |
| Appearance | White crystalline powder |
| Melting Point | 191–192°C |
| Molecular Structural Data | |
| 1. Molar Refractivity | 83.76 |
| 2. Molar Volume (cm³/mol) | 271.3 |
| 3. Parachor (90.2 K) | 670.5 |
| 4. Surface Tension (dyne/cm) | 373.3 |
| 5. Polarizability (10⁻²⁴ cm³) | 33.2 |
| 6. Monoisotopic Mass | 279.175378 Da |
| 7. Nominal Mass | 279 Da |
| 8. Average Mass | 279.848 Computational Chemical Data |
| Computational Chemical Data | |
| 1. Calculated Hydrophobicity Parameter (XlogP) | 5.4 |
| 2. Number of Hydrogen Bond Donors | 0 |
| 3. Number of Hydrogen Bond Acceptors | 1 |
| 4. Number of Rotatable Bonds | 5 |
| 5. Number of Tautomers | 0 |
| 6. Topological Polar Surface Area (TPSA) | 3.2 |
| 7. Number of Heavy Atoms | 19 |
| 8. Surface Charge | 0 |
| 9. Complexity | 275 |
| 10. Number of Isotopic Atoms | 0 |
| 11. Number of Defined Atomic Stereocenters | 0 |
| 12. Number of Undefined Atomic Stereocenters | 1 |
| 13. Number of Defined Bond Stereocenters | 0 |
| 14. Number of Undefined Bond Stereocenters | 0 |
| 15. Number of Covalently-Bonded Units | 1 |
| Shelf Life | 24 months |
| Testing Method | High-performance chromatographic and liquid-phase analysis |
| Storage Conditions | Store in a cool, dry place |
What is Sibutramine?

1. Regulates Satiety Signals: Regulates satiety signals in the body, delays the onset of hunger, reduces appetite, and minimizes excess calorie intake.
2. Suppresses Binge Eating Urges: Curbs the impulse to binge eat, helping control portion sizes and reduce the consumption of high-calorie foods.
3. Gentle Action with Low Irritation: Delivers a mild action without harsh stimulation, making it ideal for formulating capsules, powders, and various dietary supplement products.
4. Helps Create a Caloric Deficit: Assists in building a caloric deficit, enhancing overall weight management results when combined with a balanced diet and exercise.
5. Reduces Frequent Cravings: Minimizes the urge to snack constantly, helping establish regular eating habits and preventing fat accumulation.
6. Highly Stable Active Ingredient: Features stable active properties for consistent appetite regulation, offering uniform batch quality for easy product development.
Product Applications
1. Dietary Supplements: Used in the formulation of capsules, tablets, and powders designed for appetite control; helps enhance the feeling of fullness and supports the development of weight management products.
2. Functional Solid Beverages: Incorporated into products such as meal-replacement powders to help curb the desire to eat and reduce caloric intake, facilitating the creation of calorie-controlled health foods.
3. Scientific Research and Drug Development: Supplied to laboratories for pharmacological experiments, formulation screening, and research into obesity-related topics.
4. International Health Supplement Market: Raw material specifications meet export standards, supported by comprehensive documentation; supplied to overseas brands for the production of weight management products.

Testing Methods
1. Content Analysis (HPLC - High-Performance Liquid Chromatography): Utilizes reversed-phase HPLC and the external standard method (using a reference standard) to quantify the active ingredients in the raw material, ensuring precise purity assessment and quality verification for each batch.
2. Moisture Determination: Employs the Karl Fischer titration method to measure moisture content, ensuring it remains within controlled limits to prevent spoilage due to dampness and to guarantee storage stability.
3. Heavy Metal Analysis: Uses atomic absorption spectrophotometry to detect heavy metals such as lead, arsenic, and mercury, ensuring compliance with safety standards for food additives intended for export.
4. Microbiological Testing: Conducted in accordance with pharmacopeial standards to assess total aerobic microbial count, Escherichia coli, Salmonella, and other microorganisms, ensuring the raw material meets safety requirements.
5. Appearance and Identification: Involves visual inspection of physical characteristics and color, combined with infrared (IR) spectroscopy, to verify the identity and authenticity of the sample.
Product Advantages
1. Direct Sourcing & Competitive Pricing: Sourced directly from the origin, eliminating multiple layers of middlemen and their markups. We offer cost-effective appetite-suppressant raw materials, ideal for bulk procurement.
2. Consistent & Reliable Quality: Standardized production processes and rigorous quality control ensure that the specifications of every batch remain stable, guaranteeing consistency in your subsequent formulation and production.
3. Comprehensive Documentation: Each shipment includes a COA. We also support third-party testing; all data is authentic and verifiable, meeting the requirements for both R&D and export compliance.
4. Free Sample Support: Samples are available for your laboratory evaluation and preliminary formulation testing, allowing you to verify the performance of the raw materials before placing a bulk order.
5. Efficient Shipping: We maintain regular stock and process shipments on the same day an order is confirmed, ensuring rapid delivery and minimizing wait times for our clients.
Packaging and Logistics
1. Samples are sealed in vacuum-packed aluminum foil bags, which are light-proof, oxygen-impermeable, and moisture-resistant. This effectively preserves the activity of the raw materials and prevents oxidation or deterioration.
2. A variety of small-quantity options-10g, 50g, and 100g-are available to meet the needs of R&D, formulation prototyping, and testing.
3. Each bag features a dedicated product label containing the product name, batch number, and production date, ensuring complete information for laboratory traceability and management.
4. Outer packaging consists of reinforced, heavy-duty cartons to prevent crushing or damage during transit, ensuring samples arrive in perfect condition.
5. Small-quantity shipments can include a Certificate of Analysis (COA), allowing customers to conduct verification testing upon receipt.
6. Domestic sample shipments are handled via express courier, offering real-time tracking and robust, damage-resistant packaging for prompt delivery to R&D laboratories.
7. For large-volume domestic shipments, we utilize specialized freight services that offer ample capacity and cost-effectiveness, with door-to-door delivery options to ensure timely arrival at your facility.
8. International orders support both Full Container Load (FCL) and Less than Container Load (LCL) shipping, with full customs documentation provided for exports to markets in Europe, the Americas, and Southeast Asia.
9. Urgent international orders can be fulfilled via air freight, shortening lead times to meet critical R&D or production procurement requirements.
10. Throughout the process, we ensure moisture-proof and light-protected handling, select transport methods tailored to the specific characteristics of the raw materials, and provide timely logistics documentation to facilitate customs clearance and inspection.
After-Sales Service
1. Pre-sales Service: Our professional team provides consultations on raw material specifications, formulation guidance, and regulatory documentation. You may request samples, and we will assist in evaluating whether the raw materials align with your R&D requirements.
2. In-sales Service: We promptly confirm order specifications, packaging, and logistics arrangements; provide shipping documentation; track the status of your shipment in real-time; and efficiently address any questions regarding your order.
3. After-sales Service: We maintain ongoing follow-ups regarding your experience with the product. Should any issues arise, we will conduct a rapid investigation and resolution process, provide technical support, and ensure that any challenges are effectively addressed.
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