Desonide Raw Material CAS No. 638-94-8

Desonide (CAS No. 638-94-8), also known as Desonide or Hydroxyprednisolone, has the molecular formula C24H32O6 and a molecular weight of 416.507. It has a density of 1.3±0.1 g/cm³ and a melting point of 274-275°C. It appears as a white to off-white powder or crystalline solid.

Desonide is a non-fluorinated corticosteroid with anti-inflammatory activity. It acts on glucocorticoid receptors and is used in inflammation and immunology research, as well as in the treatment of endogenous eczema.

Desonide is primarily used in the manufacture of topical formulations, including creams, ointments, gels, lotions, and foams. It is indicated for hormone-responsive, non-infectious dermatological conditions such as atopic dermatitis, eczema, contact dermatitis, and seborrheic dermatitis. Its relatively mild corticosteroid activity makes it suitable for use on delicate skin areas, including the face, and in pediatric topical formulations.

● Anti-inflammatory Activity: Inhibits the release of local inflammatory mediators in the skin, helping reduce erythema, swelling, and exudation.

● Anti-allergic Activity: Relieves inflammatory skin reactions associated with allergic conditions.

● Antipruritic and Vasoconstrictive Effects: Rapidly alleviates itching and erythema associated with dermatitis.

● Topical Cream and Ointment Formulations: Used for atopic dermatitis, eczema, and contact dermatitis to relieve skin erythema, itching, and inflammation.

● Gel, Lotion, and Foam Formulations: Suitable for inflammatory skin conditions affecting delicate skin areas, including seborrheic dermatitis and nummular dermatitis. May also be used in formulations intended for pediatric patients.

● Development of Dermatological Combination Formulations: Used as a low-potency corticosteroid active pharmaceutical ingredient (API), in combination with antimicrobial and moisturizing excipients, for the development of formulations targeting allergic and non-infectious skin conditions.

● Packaging: The inner packaging consists of double-layer, sealed polyethylene (PE) bags, with aluminum containers or fiberboard drums as the outer packaging. Standard packaging options include 1 kg/aluminum container, 5 kg/aluminum container, and 25 kg/fiberboard drum. Customized packaging is available upon request. Labels include the batch number, CAS number, and expiration date.

● Storage Conditions: Protect from light and moisture. Keep tightly sealed and store in a cool, dry place.

● Packaging Specifications: Double-layer PE bags are used as the sealed inner packaging, with aluminum containers or fiberboard drums as the outer packaging. Standard sizes include 1 kg/aluminum container, 5 kg/aluminum container, and 25 kg/fiberboard drum. Customized packaging and shipping marks are available according to customer requirements.

● Transportation Precautions: Protect the product from moisture and rain throughout transportation. Avoid prolonged exposure to direct sunlight and high temperatures. Ensure that cargo is properly secured during container loading to prevent drums from colliding or sustaining damage.

● Supporting Documentation: Export and customs clearance documents can be provided, including the Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), commercial invoice, packing list, and Certificate of Origin (CO).

● Storage Requirements Upon Delivery: Upon receipt, keep the product tightly sealed, protected from light, and stored in a cool, dry place.

Logistics information will be provided promptly after dispatch, with shipment tracking and delivery confirmation follow-up. Upon delivery, packaging, quantities, and the complete set of shipping documents will be checked.

If product quality fails to meet the agreed specifications or packaging is damaged due to reasons attributable to our company, customers may provide valid supporting evidence, such as photographs and test reports, and choose either replacement or reshipment of the goods or a full refund.

We provide ongoing technical support and consultation regarding formulation development and analytical testing. Batch-related documentation is retained in our archives for long-term reference, facilitating document retrieval for repeat orders.

Important Notice: This product is intended exclusively for use in the manufacture of topical formulations. Please ensure that it is used in compliance with applicable regulations and requirements.

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