Diphenhydramine Hydrochloride is an ethanolamine-class antihistamine with the chemical formula C₁₇H₂₂ClNO and CAS No. 147-24-0. It appears as a white crystalline powder and is very soluble in water, freely soluble in ethanol or chloroform, slightly soluble in acetone, and very slightly soluble in diethyl ether or benzene. Its polarizability (10⁻²⁴ cm³) is 31.54, and the number of covalent units is 2. It primarily exerts its antiallergic effects by inhibiting histamine receptors and also exhibits sedative, anticholinergic, and antiemetic properties.
Product Description and Specifications
Diphenhydramine Hydrochloride is a first-generation ethanolamine-class antihistamine pharmaceutical raw material. It appears as a white crystalline powder. Its mechanism of action involves the competitive blockade of H1 histamine receptors, thereby inhibiting histamine-mediated responses. It also exhibits certain central nervous system depressant and anticholinergic activities.
We supply Diphenhydramine Hydrochloride API featuring high HPLC purity, stringent impurity control, consistent batch-to-batch quality, and good powder flowability. It is suitable for formulation development and evaluation across various dosage forms.
Regular stock is available. We support sample testing, small- and large-volume purchases, and international import and export operations. Each batch can be supplied with a Certificate of Analysis (COA) and a Material Safety Data Sheet (MSDS), meeting the procurement requirements of pharmaceutical formulation developers and research institutions.
| Specifications | |
| English Name | Diphenhydramine Hydrochloride |
| Chemical Formula | C17H22ClNO |
| Molecular Weight | 291.816 |
| CAS No. | 147-24-0 |
| Assay | ≥99% |
| Density | 1.024 g/cm3 |
| Melting Point | 168-172°C |
| Boiling Point | 343.7°C |
| Flash Point | 101.5°C |
| Appearance | White crystalline powder |
| Solubility | Very soluble in water, freely soluble in ethanol or chloroform, slightly soluble in acetone, and very slightly soluble in diethyl ether or benzene. |
| Molecular Structure Data | |
| Molar Refractivity | 79.56 |
| Molar Volume (cm3/mol) | 249.2 |
| Isotonic Specific Volume (90.2K) | 621.4 |
| Surface Tension (dyne/cm) | 38.6 |
| Polarizability (10-24 cm3) | 31.54 |
| Computational Chemistry Data | |
| Hydrophobic Parameter (XlogP) | N/A |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 6 |
| Tautomer Count | 0 |
| Topological Polar Surface Area | 12.5 |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 211 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
Product Applications
1. Formulation development and formulation screening trials for antihistamine preparations.
2. Laboratory-scale and pilot-scale process validation for generic drug development projects.
3. Pharmacological and pharmacokinetic research conducted by scientific research institutions and universities.
4. Establishment of pharmaceutical quality standards and validation of analytical methods.
5. Drug stability testing and accelerated aging studies.
6. Pharmaceutical raw material import and export supply, together with related custom synthesis and supporting projects.
Storage, Packaging and Transportation
1. Store the product in a tightly sealed, light-protected container in a cool, dry warehouse. Maintain the storage temperature below 25°C and the ambient relative humidity below 60%.
2. Keep away from heat sources, direct strong light, and oxidizing substances. Protect from moisture to prevent deterioration and maintain product purity and stability.
3. Small samples are packaged in vacuum-sealed aluminum foil bags to prevent exposure to air and moisture and preserve sample quality.
4. Bulk quantities are sealed in double-layer PE inner bags and packed in 25 kg fiberboard drums as outer packaging for dust and moisture protection.
5. Before dispatch, each package is individually inspected to verify seal integrity. Shipments are released to the logistics provider only after confirming that there is no packaging damage or powder leakage.
6. Transport under ambient temperature conditions. Handle with care and avoid excessive pressure and exposure to rain. For export orders, additional protection can be provided using palletization and stretch-film wrapping.
Product Advantages
Quality Advantages
Our Diphenhydramine Hydrochloride API features high HPLC purity, stringent in-house impurity controls, consistent batch-to-batch quality, and good powder flowability, making it suitable for various pharmaceutical formulations. Each batch undergoes comprehensive quality testing before release. Complete documentation, including COA and MSDS, is available to ensure product quality traceability.
Supply Advantages
Regular inventory is maintained, and orders can be arranged for dispatch on the same day upon confirmation. We support sample orders, pilot-scale requirements, and bulk purchases, with flexible packaging options to accommodate different customer needs. Global import and export services are available to support the smooth execution of customer projects.
Service Advantages
We provide comprehensive logistics support. In the event of cargo loss during transportation, full compensation will be provided. Our technical team offers professional consultation on product storage and formulation applications. We provide end-to-end order tracking and respond promptly to customer requirements to help minimize procurement risks.
After-Sales Support
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