High-Purity Clobetasol Propionate CAS 25122-46-7

Clobetasol propionate (CAS 25122-46-7), also known as clobetasol 17-propionate, is an organic compound with the molecular formula C25H32ClFO5 and a molecular weight of 466.97. It appears as an almost white to slightly yellow crystalline powder, with a melting point of 194–198°C, a boiling point of 569°C, and a density of 1.28 g/cm³.

Clobetasol propionate is a super-potent topical glucocorticoid with anti-inflammatory properties. It is indicated for the treatment of non-infectious skin conditions such as chronic eczema, neurodermatitis, and psoriasis. This substance can be absorbed through the skin; therefore, its dosage must be strictly controlled (not exceeding 50 g per week). Long-term use over large areas of the skin is not recommended. It is contraindicated in patients with bacterial or fungal skin infections or known hypersensitivity to the product.

Clobetasol propionate is a pharmaceutical raw material belonging to the super-potent glucocorticoid class. It works by inhibiting the accumulation of inflammatory cells and reducing the release of inflammatory mediators, thereby exerting anti-inflammatory, antiallergic, antiproliferative, and immunosuppressive effects. It helps alleviate localized inflammatory symptoms, including redness and swelling.

We supply high-purity clobetasol propionate API with stringent impurity controls and consistent batch-to-batch quality, making it suitable for the development of topical formulations.

This product has a rapid onset of action and is one of the most potent topical corticosteroids used in clinical practice. It exhibits strong vasoconstrictive activity in cutaneous capillaries.

Following topical application, clobetasol propionate can be absorbed through intact skin. Once absorbed, it undergoes metabolism similar to that of systemically administered corticosteroids. Metabolism occurs primarily in the liver, and metabolites are excreted through the kidneys.

Directions for Use and Dosage

For external use only. Apply a thin, even layer to the affected area 1–2 times daily. Occlusive dressing is generally not recommended, except for lesions on the palms, soles, or areas of marked hyperkeratosis. The total quantity used must not exceed 50 g per week.

1. Formulation Development: Used in the development of formulations containing super-potent topical glucocorticoids and in formulation compatibility and excipient screening. Supports pilot-scale and intermediate-scale development, scale-up, and manufacturing process validation for generic drug projects.

2. Research and Analytical Testing: Suitable for pharmacological studies investigating the anti-inflammatory effects of dermatological drugs at research institutions and laboratories. Also used in the establishment of API quality standards, analytical method validation, and formulation stability studies.

3. API Supply: Available for cross-border pharmaceutical raw material supply and import/export operations. Customized synthesis, impurity reference standard preparation, and other supporting R&D services can also be arranged according to customer requirements.

Clobetasol propionate API is assayed using high-performance liquid chromatography (HPLC), with a product purity of ≥99.0%. Individual impurities and total impurities are subject to stringent control to ensure consistent quality and batch-to-batch uniformity.

Testing is performed with reference to relevant pharmacopoeial methods, using a C18 chromatographic column and a UV detector. The assay content is calculated using the external standard method.

Additional quality control tests include identification, water content, residue on ignition, heavy metals, and related substances. A complete Certificate of Analysis (COA) is provided for each batch. All analytical data are authentic and traceable, meeting the quality control requirements of formulation development projects and international pharmaceutical buyers.

We provide comprehensive and responsive after-sales support. All products undergo stringent, full-scope quality inspections before leaving our facility to ensure that the supplied materials meet the specifications stated in their corresponding COA reports.

If customers are dissatisfied with product quality upon receipt, they may submit relevant testing documentation within the agreed claim period. Upon verification, we support a full refund.

We also provide end-to-end order tracking. In the event of cargo loss during transportation, we offer full compensation.

In addition, our technical support team is available to assist with raw material storage, formulation compatibility, and other product-related technical inquiries. We respond promptly to after-sales requests and provide comprehensive support throughout the procurement process.

Our goal is to eliminate purchasing concerns and provide domestic and international pharmaceutical R&D customers with a reliable, consistent, and secure source of high-quality raw materials.

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