Cetilistat is a gastrointestinal lipase inhibitor with a weight loss mechanism of action similar to Orlistat. The drug mainly exerts its local efficacy within the stomach and small intestine lumen and is not absorbed into the bloodstream. This product can specifically bind to gastric lipase and pancreatic lipase, inhibit the catalytic activity of the enzymes, and block the hydrolysis and breakdown of dietary triglycerides. Undigested fat cannot be absorbed by the intestinal tract and is directly excreted out of the body with feces, reducing the body's absorption of dietary fat, creating a calorie deficit, and thereby achieving weight control. Compared with Orlistat, the gastrointestinal adverse reactions of Cetilistat are milder, the incidence of side effects such as oil discharge and steatorrhea is lower, and patient tolerance is better. In addition to weight loss, it can assist in improving blood lipid levels in obese populations during the weight loss process, helping to lower total cholesterol and improve insulin resistance. It is suitable for weight management in overweight, obese, and obese populations combined with hyperlipidemia and type 2 diabetes.
Product Description and Parameters
Similar to the mechanism of Orlistat, it inhibits the activity of gastric lipase and pancreatic lipase in the gastrointestinal tract, prevents the hydrolysis of dietary triglycerides, reduces fat absorption, and discharges oil with feces to achieve weight control. It is almost not absorbed into the blood, does not act on the central nervous system, and does not suppress appetite. Compared with Orlistat, gastrointestinal oil discharge-related side effects are milder, and tolerance is better.
| Name | Cetilistat |
| Purity | 99% |
| CAS No. | 282526-98-1 |
| Molecular Formula | C25H39NO3 |
| Chemical Formula | C25H39NO3 |
| Molecular Weight | 401.59 |
| Chemical Name | 2-(hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one |
| Appearance | White to off-white crystalline powder |
| Solubility | Almost insoluble in water, easily soluble in ethyl acetate and dichloromethane, soluble in ethanol |
| Melting Point | 76～80℃ |
| Stability | Good stability under room temperature conditions, no refrigeration required; store sealed and protected from light |
| Single Impurity | ≤0.10% |
| Total Impurities | ≤0.50% |
| Water Content | ≤0.5% |
| Residue on Ignition | ≤0.1% |
| Heavy Metals (Pb, As, Cd, Hg) | ≤10 ppm |
| Testing Standard | Enterprise internal control standard; a full set of testing documents can be provided on request |
| Accompanying Documents | COA, MSDS, HPLC spectrum, IR spectrum |
| Category | Gastrointestinal lipase inhibitor |
| Site of Action | Acts locally in the stomach and small intestine, almost not absorbed into the blood |
| Mechanism | Inhibits gastric lipase and pancreatic lipase, blocks dietary triglyceride breakdown, and reduces fat absorption |
| Features | Does not act on the central nervous system, has no appetite suppression effect; compared with Orlistat, gastrointestinal oil discharge side effects are lighter, and tolerance is better |
| Metabolism | The vast majority is excreted with feces, with almost no accumulation in the body |
Product Application Fields
1. Cetilistat active pharmaceutical ingredient (API) is used to manufacture oral weight-loss tablets and serves as the core component for this new generation of gastrointestinal lipase inhibitors.
2. It is utilized in the R&D and commercial production of weight-management medications for obese or overweight adults; products based on this compound are already marketed in Japan.
3. It is used in the development of weight-loss therapies for obese individuals with co-existing hyperlipidemia or metabolic syndrome.
4. It is employed in the R&D of weight-control formulations for obese patients with type 2 diabetes.
5. It is supplied to pharmaceutical companies for the development of generic drugs and to support overseas regulatory filings.
6. It is available to contract research organizations (CROs) and scientific research institutions for studies on formulation, stability, and dissolution.
7. It is used in preclinical research, including pharmacological studies related to obesity and bioequivalence testing.
8. It can be used in formulation research for weight-management interventions in obese patients with co-existing hypertension.
9. It is used in the development of next-generation weight-loss drugs, intended as alternatives or improvements to orlistat.
10. It supports pharmaceutical manufacturers in conducting small-scale trials and pilot-scale production for various tablet dosage strengths.
11. It is used in fundamental research on metabolic diseases to explore the impact of inhibiting fat absorption on lipid metabolism.
Testing Methods
HPLC High-Performance Liquid Chromatography
Measures main content, simultaneously testing single impurity and total impurities, which is the core testing method for this product.
IR Infrared Spectroscopy
Used for raw material identification, comparing characteristic absorption spectra to confirm the chemical structure of Cetilistat.
Karl Fischer Water Content Determination
Tests sample water content, controlling raw material moisture to ensure storage stability.
Residue on Ignition Inspection
Weighing after high-temperature ignition to determine inorganic residual impurity content.
Heavy Metals Testing
Adopting ICP or atomic absorption spectrophotometry to test heavy metal residues such as lead, arsenic, cadmium, and mercury.
Microbial Limit Inspection
Tests total aerobic microbial count, molds, yeasts, and controlled bacteria to meet API microbial quality control standards.
Product Advantages
1.Product purity is high, HPLC content ≥99.0%, strictly controlling impurities, with single impurity ≤0.10% and total impurities ≤0.50%.
2.Product quality is stable, with mature synthesis technology, small batch variation, and stable physical and chemical indicators, suitable for continuous production of preparations.
3.Spot inventory is sufficient, supporting sample and bulk orders, with fast shipping, and samples can be quickly arranged to be sent out.
4.This product can be stored at room temperature without cold chain transportation, reducing customer storage and logistics costs.
5.Compared with Orlistat, gastrointestinal side effects are milder, patient tolerance is better, and the preparation market potential is huge.
6.Full-item testing for each batch, providing complete data of COA, MSDS, HPLC, and IR, facilitating overseas application.
7.Packaging adopts double-layer light-proof protection of vacuum aluminum foil bag + fiber drum, effectively preventing moisture and oxidation.
8.Flexibly providing lab-scale samples, pilot-scale, and ton-level bulk supply to meet customer needs at different stages.
Packaging Methods and Logistics
1.The inner layer is sealed and packaged in a vacuum aluminum foil bag, which is light-proof and moisture-proof, effectively isolating air to protect raw materials.
2.Bulk goods use fiber drums as outer packaging, with regular specifications: 1 kg/bag, 5 kg/drum, 25 kg/drum.
3.Product name, CAS No., batch number, net weight, and expiry date are clearly marked on the drum body, and neutral packaging can be provided.
4.This product is stable at room temperature and does not require cold chain transportation, significantly reducing customer logistics and storage costs.
5.Samples are packaged in small aluminum foil packaging, sent via regular express/international express DHL and FedEx.
6.Large-batch orders can choose air freight or sea freight; transportation only requires being dry and protected from light, avoiding sun exposure and high temperatures.
7.Shipments are accompanied by a COA, MSDS, packing list, and commercial invoice to meet overseas customs clearance needs.
8.Goods are prohibited from mixed loading with strong oxidants, strong acids, and strong alkalis; tracking numbers are provided in time after shipment to follow up on logistics.
After-Sales Service
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